The diagnosis of nodal and extranodal lymphoid proliferations has become progressively more complex, and the number of widely available ancillary tests has continued to grow. The general surgical pathologist faces the challenge of selecting the best tests to arrive at a precise diagnosis in a cost-effective manner, and then knowing how to interpret sometimes misleading or conflicting results. This course is designed to provide guidance in the routine workup of lymphoproliferative disorders for general surgical pathologists, residents and hematopathology fellows in training. Common situations rather than exotic entities that often require a consultant will be emphasized, and audience participation will be encouraged using an audience response system.

The course will begin with an introduction to handling lymph node and related tissue biopsies that will review the major ancillary techniques used in diagnostic hematopathology including their strengths and weaknesses. An algorithmic approach to the evaluation of nodal and extranodal lymphoid proliferations (excluding bone marrow) will be provided. The remainder of the course will consist of case-based presentations, chosen to be representative of the situations most likely to be encountered in a general surgical pathology practice. Presentations will emphasize problem solving, starting with the clinical situation and routine histopathology and ending up with a confident diagnosis, with attention paid to common pitfalls that might arise along the way.

Virtual slides of the major cases to be discussed and brief histories will be provided on the USCAP website for review by pre-registrants prior to the meeting. A written syllabus and printed copy of the PowerPoint presentations will be distributed at the course. After the course, all participants will receive web access to PowerPoint material along with the text portion of the syllabus.

Upon completion of the course, participants will be able to: 1) develop a protocol for handling hematopathology specimens in a general surgical pathology practice, 2) employ a multiparameter approach for evaluating lymphoid proliferations integrating histopathology with readily available ancillary tests and know when to obtain external consultation, 3) be aware of the more recent changes in diagnostic hematopathology as they relate to the diagnosis of the more common types of lymphomas, and 4) recognize potential pitfalls in the interpretation of lymphoid proliferations.

(NEW COURSE) This course may be used for CME credits or SAM credits.