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Monday, February 28, 2011 7:50 a.m. – 1:00 p.m.
A PRACTICAL GUIDE TO MOLECULAR TESTING IN CANCER



COURSE DIRECTOR:
Julia A. Bridge, M.D., FACMG
Department of Pathology & Laboratory Medicine
University of Nebraska Medical Center
Omaha, Nebraska
Course Description
Accumulating discoveries of the biological mechanisms that control cell growth and differentiation, and developments in the clinical management of cancer, continue
to expand the role of molecular technology in diagnostic surgical pathology. In this course, the fundamental principles of molecular pathology in cancer and their
application to laboratory medicine will be emphasized in a format designed to be practical and straightforward. Specifically, this course is aimed at providing pathologists
with a foundation in the practice of oncologic molecular pathology to include: nomenclature, commonly used techniques and their specimen requirements, assay
selection and indications, diagnostic and prognostic utility, test turn-around-times, and quality assurance issues. Select cases may be presented to illustrate use in
routine practice and serve as useful paradigms. Moreover, specific areas will be highlighted in which major advances can be expected and to which the key principles
learned can be applied.

Course Objectives:
- To present an overview of the central genetic principles of oncologic molecular tests commonly used in the practice of pathology.

- To provide participants with a working knowledge of tests available in oncologic molecular pathology as well as their application and interpretation in
screening, diagnosis, monitoring, and treatment of cancer.
| Introduction
Julia A. Bridge, M.D., FACMG, University of Nebraska Medical Center, Omaha, NE |
| Clinical Cytogenetic and Molecular Genetic Testing in Bone and Soft Tissue Tumors
Julia A. Bridge, M.D., FACMG, University of Nebraska Medical Center, Omaha, NE |
| Breast Cancer: Molecular Pathology as Applied to Clinical Practice
Michael F. Press, M.D., Ph.D., Keck School of Medicine, University of Southern California, Los Angeles, CA |
| Molecular Markers for Targeted Lung Cancer Therapy
John Iafrate, M.D., Ph.D., Massachusetts General Hospital, Boston, MA |
| Molecular Pathology of Neoplasms of the Kidney and Urinary Tract
Victor E. Reuter, M.D., Memorial Sloan Kettering Cancer Center, New York, NY |
| Molecular Diagnostics of Lymphoma: Assays for Classification, Outcome Prediction and Therapy Response
Dan Jones, M.D., Ph.D., Quest Diagnostics Nichols Institute, Chantilly, VA |
| GIST and Melanoma: The KIT Connection and So Much More
Alexander Lazar, M.D., Ph.D., University of Texas M. D. Anderson Cancer Center, Houston, TX |
| Colorectal Cancer: Molecular Testing for the Surgical Pathologist
Kevin C. Halling, M.D., Ph.D., Mayo Clinic, Rochester, MN |
| Molecular Diagnostics of Gliomas
Arie Perry, M.D., University of California, San Francisco, San Francisco, CA |
| Question Period and Concluding Remarks
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