SPECIAL COURSE

 Tuesday, March 1, 2011   —  8:00 a.m. - 1:00 p.m.

ADVANCED MOLECULAR PATHOLOGY



COURSE DIRECTOR:
Frederic G. Barr, M.D., Ph.D.
Department of Pathology & Laboratory Medicine
University of Pennsylvania School of Medicine
Philadelphia, PA

Course Description
This special course will provide an in-depth consideration of recent advances in molecular biology and genetics that are enhancing the understanding of the pathogenesis of human cancer and other diseases, and impacting on the practice of diagnostic pathology. Topics will be chosen to highlight specific advances in the molecular and cell biology related to disease pathogenesis, with considerations of molecular mechanisms, genetic and cellular signaling pathways, and various methodologic approaches. The program is designed as an update for both practicing pathologists and primary investigators on these specific topics, as well as general trends in the field of molecular pathology. In addition to presenting a basic scientific foundation on each topic, these lectures will provide practical information concerning how this information can be applied in diagnostic and therapeutic settings. Therefore, an important overall emphasis of this course will be translational issues that link basic discoveries with the practice of pathology.

Introduction
Frederic G. Barr, M.D., Ph.D., University of Pennsylvania School of Medicine, Philadelphia, PA
The Acquisition of Mutations in Neoplasia
Lawrence A. Loeb, M.D., Ph.D., University of Washington School of Medicine, Seattle, WA
Molecular Pathology of Colorectal Cancer: Deciphering Complex Multifactorial Diseases
Shuji Ogino, M.D., Ph.D., Harvard Medical School, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA
Next Generation Sequencing and Integrated Analysis of the Cancer Genome
Javed Khan, M.D., National Cancer Institute, Bethesda, MD
Molecular Pathology of Prostate Cancer: Biological and Clinical Implications
Michael Ittmann M.D., Ph.D., Baylor College of Medicine, Houston, TX
Metastasis Genetics, Epigenetics and the Tumor Microenvironment
Danny R. Welch, Ph.D., University of Alabama at Birmingham, Birmingham, AL
Genomic Analysis of Acute Lymphoblastic Leukemia: Insights into Biology, Diagnosis, and Therapy
Cheryl L. Willman, M.D., University of New Mexico, Albuquerque, NM