Role of Molecular Studies in Management of Non-Small Cell Lung Cancer (NSCLC) Samuel A. Yousem, M.D. University of Pittsburgh School of Medicine Pittsburgh, PA

Clinical History This 67 year old man with a cigarette smoking history presented with cough and weight loss. CT scan showed a spiculated right upper lobe mass for which he underwent lobectomy. The resected lobe showed a centrally necrotic 4.5 cm mass in the apex. After lobectomy additional mediastinal (right level 4) lymph nodes were sampled. Molecular testing of his tumor revealed an EGFR Exon 21 mutation (L858R). Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Click here to download handout in pdf format for this case.