This is a practically oriented course that will present basic concepts in endocrine pathology to allow a logical approach to difficult diagnoses in endocrine pathology. Tumors with borderline features and needle biopsies of tumors will be presented. Glass slides of H&E sections of each case will be made available. Differential diagnosis will be generated for each lesion with specific diagnostic criteria. Immunohistochemical studies useful in the differential diagnoses will be presented. Molecular genetic findings and mechanisms involved in these conditions will be discussed. The course will present a practical approach for pathologists, fellows, and residents for the diagnosis of endocrine tumors with emphasis on the diagnostic criteria in difficult areas of endocrine pathology.

A virtual slide and still images, along with histories, will be posted on the USCAP website for review by pre-registrants prior to the meeting. A syllabus reviewing diagnostic features and differential diagnoses will be distributed at the meeting. All course registrant will also receive web access to the PowerPoint presented at the USCAP Annual Meeting along with the text portion of the syllabus.

Upon completion of this course, participants will be able to: 1) Generate differential diagnoses and list criteria used to diagnose borderline endocrine lesions and lesions obtained by needle biopsies with limited samples. 2) Understand the immunohistochemical markers useful in the diagnosis of common endocrine lesions and the molecular basis for this conditions.3) Have a working knowledge of the clinical significance of the diagnoses.

(NEW COURSE) This course may be used for CME credits or SAM credits.