—  SPECIALTY CONFERENCE HANDOUT  — Gynecologic Pathology Monday, February 28, 2011, 7:30 PM CC 103 A/B Clinical histories are printed below. Click on the case numbers for text and references of each case. Click on each slide thumbnail image for an enlarged view Two Debates in Gynecologic Pathology Moderator: RICHARD ZAINO Hershey Medical Center Hershey, PA Disclosure: In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Symposium) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. The speakers listed below have indicated they have nothing to disclose. Panelists: Case #1: CIN ll Exists Pro: Christopher Crum, Brigham and Women’s Hospital, Boston, MA Con: Mark Stoler, UVA Health System, Charlottesville, VA Case #2: Once Low Grade Serous Tumors Have Been Eliminated, Serous LMP Tumors Are Benign Pro: Robert Kurman, Johns Hopkins University School of Medicine, Baltimore, MD Con: Robert Soslow, Memorial Sloan-Kettering Cancer Center, New York, NY Clinical histories are displayed below. For the fastest viewing of virtual slides, click: under each thumbnail image below. You must have Aperio ImageScope installed on your PC. If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy:   Or, click on slide thumbnail images to view each slide in a Web-based slide viewer, which is somewhat slower. If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137. Case 1 CIN II Exists – Pro - Click here for Text and References Submitted by: Christopher P. Crum - Clinical Summary: Three cases (8 images) of cervical specimens are supplied for your review. Review each set of images in each case and grade the lesion in each of the images. Then, give your diagnosis for the case. Each image and case will be discussed at the session, which will focus on the existence (or non-existence) of CIN2. Case 1a - Figure 1 Case 1a - Figure 2 Case 1a - Figure 3 Case 1b - Figure 1 Case 1b - Figure 2 Case 1c - Figure 1 Case 1c - Figure 2 Case 1c - Figure 3 Case 1 CIN II Exists – Con - Click here for Text and References Submitted by: Mark H. Stoler - Clinical Summary: 28 year old woman with a history of recurrent cervical dysplasia, who’s most recent cervical vaginal cytology was interpreted as HSIL (moderate dysplasia). This scanned slide and jpeg images provided for your review are from a subsequent simple hysterectomy. Case 1 - Figure 1 Case 1 - Figure 2 Case 1 - Figure 3 Case 1 - Figure 4 Case 1 - Figure 5 Case 2 Once Low Grade Serous Tumors Have Been Eliminated, Serous LMP Tumors are Benign – Pro - Click here for Text and References Submitted by: Robert J. Kurman - Clinical History: A 34 year old woman was found to have a pelvic mass and a serum CA-125 of 800. A TAH, BSO, and omentectomy were performed. A virtual slide of the 5 cm diameter right ovary is provided for your review as well as images of the ovary and omentum. Case 2 - Figure 1 Case 2 - Figure 2 Case 2 - Figure 3 Case 2 - Figure 4 Case 2 - Figure 5 Case 2 - Figure 6 Case 2 Once Low Grade Serous Tumors Have Been Eliminated, Serous LMP Tumors are Benign – Con - Click here for Text and References Submitted by: Robert A. Soslow - Clinical Summary: The patient is 45 years old and reported abdominal fullness. Physical examination revealed large pelvic masses that were thought to represent bilateral adnexal masses on ultrasound. Serum CA125 was elevated. Exploratory laparotomy revealed bilateral adnexal masses and implants involving uterine serosa, cul de sac and omentum. Frozen section revealed serous borderline tumor. The patient underwent staging and debulking surgery that included TAHBSO, omentectomy and lymphadenectomy. Case 2 - Figure 1 Case 2 - Figure 2 Case 2 - Figure 3 Handouts for all Specialty Conferences will be accessible via the "Educational Materials" section on the homepage the morning after each respective conference. Printed copies of the handout will not be available at the meeting.