This short course will enable confident diagnosis of various reactive, benign and neoplastic glandular lesions on Pap Tests. The course discussion will evolve around 10 wide-ranging cases. Emphasis will be placed on morphological appearances of glandular structures, normal and abnormal, on liquid-based preparations. Comparative analysis of various lesions on conventional smears will be reviewed. Common artifacts, diagnostic dilemmas, and potential pitfalls will be highlighted. Role of HPV-testing in endocervical lesions will be outlined. Current diagnostic and management guidelines will be reviewed. Importance of histological and clinical correlation will be emphasized. Related quality assurance issues will be addressed. Pre-registrants will be able to view virtual slides and still images from the 10 illustrative cases, and attempt related multiple-choice questions (in advance at www.uscap.org). A syllabus will be distributed to registrants at the meeting. An interactive approach with the audience, with question-answer sessions and discussion periods, will ensure audience participation. Post-meeting, all participants will receive web access to the PowerPoint presentation with the text portion of the syllabus. Practicing pathologists fellows and residents will benefit from this course.

Upon completion of the course, participants should be able to: 1) diagnose various glandular lesions on liquid-based Pap Tests; 2) recognize differences in appearance of these lesions on conventional and liquid-based preparations; 3) utilize ancillary tools, including immunocytochemistry and HPV-testing; 4) realize limitations of cytological diagnoses; and 5) understand current management guidelines.

(LAST SCHEDULED PRESENTATION) This course may be used for CME credits or SAM credits.