This course is intended to provide an update regarding the rapidly evolving field of molecular testing in cancer. It is already apparent that advances in this field have started to make a significant mark in the diagnosis and management of cancer patients, as well as lead into a new era of cancer care which goes far beyond anatomical diagnosis. The targeted audiences of this course are practicing anatomical pathologists, pathology residents, and fellows. An extensive syllabus will be distributed at the course. After the meeting all participants will receive web access to PowerPoint material along with the text portion of the syllabus.

We will provide an overview of the scope of applications of molecular testing in cancer, from diagnostic, prognostic, to predictive applications with commonly used examples in clinical practice as well as a quick overview of the principles of the most commonly used techniques. Using illustrative cases, we will discuss the role of molecular testing in colorectal cancer and its impact on patient management. Also, we will provide an update on testing epidermal growth factor receptor and KRAS gene expression in different tumors. A brief overview of the emerging role of "microRNA" testing in cancer care will be presented. Finally, we will introduce the concept of "personalized medicine" and provide an overview of the scope of clinical application of personalized medicine in cancer management. We will conclude by addressing some practical challenges which face the incorporation of molecular testing into our pathology practice.

Upon completion of the course, it is anticipated that participants will be able to: 1) Describe the increasingly important role and limitations of molecular pathology in current practice and its effect on cancer patient diagnosis and management; 2) Explain the basic principles of the molecular methods used in clinical practice; 3) Point out how molecular testing can be incorporated into our pathology practice; and 4) Define the concept of "personalized medicine" and its scope of applications in cancer management.

(LAST SCHEDULED PRESENTATION) This course may be used for CME credits or SAM credits.