Sunday, March 18, 2012 8:30 a.m. Convention Centre Ballroom A/B
- Familial Cancer Syndromes: The Role of the Surgical Pathologist
Vania Nose, University of Miami Miller School of Medicine, Miami, FL and Jason L. Hornick, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
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||Introduction - Christopher D. M. Fletcher, Brigham and Women's Hospital, Boston, MA and Vania Nose, University of Miami, Miami, FL and Jason L. Hornick, Brigham and Women's Hospital, Harvard Medical School, Boston, MA |
||President's Award - Christopher D. M. Fletcher, Brigham and Women's Hospital, Boston, MA|
|| Familial Cancer Syndromes Involving the GI Tract - Joel Greenson, University of Michigan, Ann Arbor, MI|
||Familial Cancer Syndromes Involving the Breast - Jorge Reis-Filho, Institute of Cancer Research, London, U.K.|
|| Familial Cancer Syndromes Involving the Ovary - Christopher P. Crum, Brigham and Women's Hospital, Boston, MA|
|| Familial Cancer Syndromes Involving the Endocrine System - Sylvia Asa, University of Toronto, Toronto, Canada|
|| Familial Cancer Syndromes Involving the Peripheral Nervous System - Cristina Antonescu, Memorial Sloan-Kettering Cancer Center, New York, NY|
|| Familial Cancer Syndromes Involving the Kidney - Jesse McKenney, Stanford School of Medicine, Stanford, CA|
|The topic was chosen by the President, the Officers, the Committee members and the Co-Chairs of the Program Committee of the Arthur Purdy Stout Society because of the emerging knowledge of familial cancer syndromes and the crucial role of the surgical pathologist in diagnosing these syndromes.
Pathologists have played a pivotal role in recognizing genotypic-phenotypic correlations in families with hereditary cancer syndromes, leading to the identification of histological characteristics that can help predict the presence or absence of germline mutations of specific cancer predisposition genes.
This symposium will provide important paradigms in the study of the molecular basis of tumorigenesis and the identification of molecular mechanisms underlying inherited syndromes. In addition to providing an update of our current understanding of the pathologic manifestation of the important familial cancer syndromes in different organ systems, this symposium will also focus specifically on the role of the surgical pathologist, including a discussion of the pathologic features that should suggest specific syndromic associations, and what additional work-up might be appropriate either to diagnose such a syndrome or to provide other important prognostic or predictive information.