Emerging data indicates that the pathologist's skill in detecting cervical glandular precursor lesions is critical to the detection of precursor and early invasive cervical adenocarcinoma. This course is designed to increase the diagnostic expertise of pathologists and pathologists-in-training in the interpretation of glandular lesions encountered in cervical cytology, curettage, and biopsy specimens, as well as hysterectomy specimens. This case-based, didactic course provides the essential tools for interpretation of morphologic, immunohistochemical, and molecular diagnostic tests in the assessment of cervical specimens. The role of high-risk HPV, key cytologic findings and mimics, current ASCCP management guidelines, use of biomarkers in determining site of origin, and proper grossing techniques will be addressed. Emphasis will be placed on correlating cervical cytology findings with those in the corresponding tissue sample. Upon completion of this course, participants should be able to: 1) implement proper gross prosection techniques for cervical cone specimens and hysterectomy specimens; 2) recognize the various subtypes of adenocarcinoma, and; 3) reproducibly diagnose adenocarcinoma in situ and invasive adenocarcinoma arising in the cervix. The participant will also be able to list and recognize the common mimics of in situ and invasive cervical adenocarcinoma and reliably distinguish cervical and endometrial carcinoma in the uterine curettage/biopsy. This course will include opportunities for active audience participation, and is intended for general pathologists, gynecological pathologists, cytopathologists, residents and fellows. Digital case images will be available for review on the USCAP website prior to the course and a syllabus will be provided to participants at the course. Registrants will also have access to after meeting materials on the USCAP website.

(NEW COURSE) This course may be used for CME credits or SAM credits.