Case 2 -

CON: EIN is Superior to WHO in the Diagnosis and Management of Precursors of Endometrioid Adenocarcinoma Lora Hedrick Ellenson, New York Presbyterian Hosp, New York, NY

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Clinical History Case A. 54 year old woman with postmenopausal bleeding Case B. 34 year old woman with irregular bleeding Case C. 40 year old woman with menometrorrhagia Case 2A - Figure 1 Case 2A - Figure 2 Case 2A - Figure 3 Case 2B - Figure 1 Case 2B - Figure 2 Case 2B - Figure 3 Case 2C - Figure 1 Case 2C - Figure 2 Case 2C - Figure 3 References: Mutter GL, Baak JP, Crum CP, Richart RM, Ferenczy A, Faquin WC. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol. 2000 Mar;190(4):462-9. Mutter GL. Histopathology of genetically defined endometrial precancers. Int J Gynecol Pathol. 2000 Oct;19(4):301-9. Mutter GL, Ince TA, Baak JP, Kust GA, Zhou XP, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res. 2001 Jun 1;61(11):4311-4. Lacey JV Jr, Mutter GL, Ronnett BM, Ioffe OB, Duggan MA, Rush BB, Glass AG, Richesson DA, Chatterjee N, Langholz B, Sherman ME. PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma. Cancer Res. 2008 Jul 15;68(14):6014-20. Lacey JV Jr, Mutter GL, Nucci MR, Ronnett BM, Ioffe OB, Rush BB, Glass AG, Richesson DA, Chatterjee N, Langholz B, Sherman ME. Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies. Cancer. 2008 Oct 15;113(8):2073-81. Silverberg SG. Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. Mod Pathol. 2000 Mar;13(3):309-27.