Case 1 - Click here for Text and References
Submitted by: Christina S. Kong
41 year old woman with ASC-US diagnosis on recent cervical cytology and positive high-risk HPV test. Colposcopy with cervical biopsy was performed.
Case 2 - Click here for Text and References
Submitted by: Anna Yemelyanova
48 year-old HIV positive woman with a history of abnormal Pap smears and vulvar condylomata. She presents with recurrence of vulvar "warts".
Case 3 - Click here for Text and References
Submitted by: Michael H. Roh
53 year old woman who presented with postmenopausal bleeding and uterine fibroids. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The images are taken from an incidental finding in the right fallopian tube.
Case 4 - Click here for Text and References
Submitted by: Joseph T. Rabban
This 50 year old G1P1 woman presented with pelvic pain and abdominal distension. Physical exam revealed a palpable pelvic mass which, on radiologic imaging, was a complex solid-cystic mass. Serum CA125 was elevated (120 U/ml). Exploratory laparotomy revealed bilateral ovarian masses and peritoneal carcinomatosis. Total abdominal hysterectomy, bilateral salpingo-oophorectomy and tumor debulking was performed. The main gross pathologic finding was bilateral solid-cystic, necrotic ovarian masses (4 cm and 14 cm) and several peritoneal samplings contained solid irregularly nodular dense tissue. Aside from serosal excrescences, the fallopian tubes, uterine body and cervix were grossly normal. The patient reported a distant history of breast cancer and of biliary tract adenocarcinoma and had previously received chemotherapy; the surgeries and treatment were performed at another institution. She did not report any history of gynecologic disease, nor any family history of breast or gynecologic cancer. She was not of Ashkenazi Jewish family background. The submitted virtual slides are of one of the fallopian tubes (H&E stain and p53 immunohistochemical stain). The tumor in the ovaries and serosal deposits exhibited similar morphology and p53 positivity.