Michael Torbenson, MD, The Johns Hopkins University School of Medicine, Baltimore, MD
Sanjay Kakar MD, University of California, San Francisco, San Francisco CA
There has been a rapid advance in our understanding of hepatic neoplasms over the past several years. This has led to (1) the description of new entities, (2) reclassification of some old entities, (3) improvements in diagnostic sensitivity and specificity for primary liver tumors with new immunostains, and (4) new medical treatments for hepatocellular carcinoma. All of these new changes add to the challenge of evaluating hepatic neoplasms! The goal of this course is to update attendees on these new advances so that these new advances can be incorporated into daily practice.
This course is designed for both pathologists-in-training and general surgical pathologists, as well as those with special interest in liver pathology. Emphasis will be placed on a thorough discussion of the recent developments in diagnostic pathology of hepatocellular neoplasms.
The course is composed of carefully selected case presentations that highlight key diagnostic points for focal nodular hyperplasia, hepatic adenomas (including all subtypes), typical hepatocellular carcinomas, and variant hepatocellular carcinomas. The accompanying discussion will provide a comprehensive overview of histological features of these entities, the intelligent use of immunostain panels, and the differential diagnoses with a focus on diagnostic pitfalls. We will also discuss additional diagnostic techniques including molecular pathology, recent advances in the understanding of pathogenesis, and how the pathology findings related to patient management.
For each case, a virtual slide and still images will be posted on the USCAP website for review by pre-registrants prior to the meeting. A syllabus reviewing diagnostic features and the differential diagnosis will be distributed at the meeting. The text syllabus will contain all of the key tables and figures presented for each case. In addition, all course registrants will receive online access to the USCAP website for the full PowerPoint presentation used at the Annual Meeting.
Upon completion of this educational activity, participants should be able to: 1) Accurately diagnose focal nodular hyperplasia, hepatic adenomas, typical hepatocellular carcinomas, and variant hepatocellular carcinomas using a) key histological findings; b) judicious use of immunostains; and c) ancillary methods; 2) Explain the clinical and treatment implications of their diagnoses; and 3) Update the pathogenesis of these entities including an update on new molecular findings.