THE VALUE OF IMMUNOHISTOCHEMISTRY IN THE ASSESSMENT OF BONE MARROW DISORDERS
Attilio Orazi, M.D., FRCPath. and Dennis P. O'Malley, M.D.
CD79a is a monoclonal antibody which is reactive to a majority of B lymphocytes. It is positive in many
acute lymphoblastic leukemias, in B cell lymphomas, and negative in the vast majority of T cell lymphomas.
It is of value as an additional B cell marker in association with CD20 and can be of great value in cases
when CD20 is negative. An antigen retrieval technique is advised. Staining is equally effective in
formalin and in B5 fixative and appears resistant to decalcification.
Mason et al. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples. Blood.