THE VALUE OF IMMUNOHISTOCHEMISTRY IN THE ASSESSMENT OF BONE MARROW DISORDERS
Attilio Orazi, M.D., FRCPath. and Dennis P. O'Malley, M.D.
CD138 is an optimal marker for plasma cell detection and enumeration in conventionally processed bone marrow
sections. Virtually all the normal and neoplastic plasma cells express this antigen. However, in contrast
with previously reported data we found reactivity in immunoblastic lymphoma and in Reed-Sternberg cells of
rare cases of classical Hodgkin's disease. Tumoral epithelial tissue can also express CD138.
Chilosi et al: CD138/syndecan-1: a useful immunohistochemical marker of normal and neoplastic plasma
cells on routine trephine bone marrow biopsies. Mod Pathol. 1999 Dec;12(12):1101-6.
Costes et al: The Mi15 monoclonal antibody (anti-syndecan-1) is a reliable marker for quantifying
plasma cells in paraffin-embedded bone marrow biopsy specimens. Hum Pathol. 1999 Dec;30(12):1405-11.
Watanabe et al: Varied B-cell immunophenotype of Hodgkin/Reed-Sternberg cells in classic Hodgkin's
disease. Histopathol 2000; 36:353-61.