Clinical History:
Case 11: This 40 year old woman had a pigmented lesion present
on the shoulder for 2 years that gradually increased in size. A sentinel lymph node biopsy was negative.
Diagnosis: Melanoma, superficial spreading type, level IV, 3.6 mm.
Case 11 - Figure A - Intermediate power micrograph shows numerous cytotoxic lymphocytes admixed with neoplastic vertical growth phase melanoma cells.
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Case 11 - Figure B - This intermediate power micrograph shows sheets of loosely cohesive fully transformed malignant epithelioid melanocytes admixed with lymphocytes.
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Case 12: This 34 year old woman with stage 4 melanoma showed a
vigorous 30 cm diameter response to autologous melanoma cells transfected with GM-CSF.
Diagnosis: positive vaccination reaction.
Case 11 - Figure C - A high power micrograph shows cytotoxic lymphoid cells in apposition to a neoplastic melanocyte showing degenerating cytosol.
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Case 11 - Figure D - A CD8 preparation shows cytotoxic lymphoid cells infiltrating the vertical growth phase component.
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