
/* Sequence of slide descriptions */
desc11 =  'Case 1 - Figure 1</font><br><font id=normaltext>The biopsy shows ballooning degeneration of the epidermis. There is a mixed inflammatory infiltrate involving the dermis and showing exocytosis.  Abundant karryorhexis is present.                                                                                      ';
desc12 =  'Case 1 - Figure 2</font><br><font id=normaltext>High-magnification shows ballooning degeneration and inflammation of the epidermis.  Several keratinocytes show intracytoplasmic viral inclusions that have a tendency to abut the nucleus.                                                                              ';
desc21 =  'Case 2 - Figure 1</font><br><font id=normaltext>Scanning magnification shows massive dermal edema.                                                                                                                                                                                                                       ';
desc22 =  'Case 2 - Figure 2</font><br><font id=normaltext>High-power magnification shows mixed acute and chronic inflammation, numerous extravasated red blood cells, and fibrin thrombi in small vessels.                                                                                                                         ';
desc23 =  'Case 2 - Figure 3</font><br><font id=normaltext>In areas, extensive necrosis is seen.                                                                                                                                                                                                                                    ';
desc24 =  'Case 2 - Figure 4</font><br><font id=normaltext>Gram stain shows numerous large gram-positive rods.                                                                                                                                                                                                                      ';
desc31 =  'Case 3 - Figure 1</font><br><font id=normaltext>There is a plaque on the left buttock, some 8x5 cm in diameter. It is not in continuity with the anal canal.                                                                                                                                                             ';
desc32 =  'Case 3 - Figure 2</font><br><font id=normaltext>The biopsy shows psoriasiform hyperplasia overlying markedly dilated dermal lymphatic spaces.                                                                                                                                                                            ';
desc33 =  'Case 3 - Figure 3</font><br><font id=normaltext>The dilated lymphatic spaces contain clusters of endovascular histiocytes.                                                                                                                                                                                               ';
desc34 =  'Case 3 - Figure 4</font><br><font id=normaltext>The dilated lymphatic spaces contain clusters of endovascular histiocytes.                                                                                                                                                                                               ';
desc41 =  'Case 4 - Figure 1</font><br><font id=normaltext>There is an ulcerative and pustular lesion of the forearm with a raised, rolled lesional edge.                                                                                                                                                                           ';
desc42 =  'Case 4 - Figure 2</font><br><font id=normaltext>There is pseudoepitheliomatous hyperplasia of the epidermis in this biopsy from the lesional edge.                                                                                                                                                                       ';
desc43 =  'Case 4 - Figure 3</font><br><font id=normaltext>The dermis contains neutrophilic microabscesses and there is neutrophilic dermal connective tissue lysis.                                                                                                                                                             ';
desc44 =  'Case 4 - Figure 4</font><br><font id=normaltext>A Sweet\'s-like vascular reaction is seen around blood vessels peripheral to the zone of maximal tissue pathergy.                                                                                                                                                        ';
desc51 =  'Case 5 - Figure 1</font><br><font id=normaltext>There is a striking sclerodermoid tissue reaction involving the dermis characterized by widened collagen bundles arranged parallel to the long axis of the epidermis.                                                                                                    ';
desc52 =  'Case 5 - Figure 2</font><br><font id=normaltext>There is prominent deposition of C5b-9 within the microvasculature of the skin corroborative of in vivo activation of the complement cascade sequence and hence indicative of a humorally mediated microangiopathy syndrome mediated by anti-endothelial cell antibodies. RT in situ PCR shows parvovirus B19 and TNF transcript expression in endothelia and in pervascular mononuclear cells (arrows).';
desc53 =  'Case 5 - Figure 3</font><br><font id=normaltext>A lung biopsy shows homogeneous septal expansion with associated vascular drop out.                                                                                                                                                                                      ';
desc54 =  'Case 5 - Figure 4</font><br><font id=normaltext>Direct immunofluorescent studies show granular deposition of IgG within the septal capillaries                                                                                                                                                                           ';
desc55 =  'Case 5 - Figure 5</font><br><font id=normaltext>Nested PCR B19 specific DNA analysis revealing a positive result for the patient\'s skin and lung samples                                                                                                                                                                ';
desc61 =  'Case 6 - Figure 1</font><br><font id=normaltext>There is a necrotizing neutrophil rich vasculitis involving the skin.                                                                                                                                                                                                    ';
desc62 =  'Case 6 - Figure 2</font><br><font id=normaltext>An open lung biopsy shows a necrotizing capillaritis                                                                                                                                                                                                                     ';
desc63 =  'Case 6 - Figure 3</font><br><font id=normaltext>In situ hybridization studies for CMV RNA transcript expression reveals positive staining of endothelial cells.                                                                                                                                                          ';
desc71 =  'Case 7 - Figure 1</font><br><font id=normaltext>There is a superficial and deep perivascular mononuclear cell infiltrate with exocytosis.                                                                                                                                                                                ';
desc72 =  'Case 7 - Figure 2</font><br><font id=normaltext>There is a pronounced lymphocytic interface dermatitis that obscures the dermoepidermal juncttion.                                                                                                                                                                       ';
desc73 =  'Case 7 - Figure 3</font><br><font id=normaltext>There is a pronounced lymphocytic interface dermatitis that obscures the dermoepidermal juncttion.                                                                                                                                                                       ';
desc74 =  'Case 7 - Figure 4</font><br><font id=normaltext>Nuclear debris is present in the dermis.                                                                                                                                                                                                                                 ';
desc75 =  'Case 7 - Figure 5</font><br><font id=normaltext>The infiltrate comprises an admixture of CD4- and CD8-expressing lymphocytes and CD68-expressing histiocytes.                                                                                                                                                            ';
desc76 =  'Case 7 - Figure 6</font><br><font id=normaltext>The infiltrate comprises an admixture of CD4- and CD8-expressing lymphocytes and CD68-expressing histiocytes.                                                                                                                                                            ';
desc81 =  'Case 8 - Figure 1</font><br><font id=normaltext>There are cord-like cutaneous lesions with plaques on the trunk.                                                                                                                                                                                                         ';
desc82 =  'Case 8 - Figure 2</font><br><font id=normaltext>There is a mid- and deep-dermal perivascular and interstitial mononuclear cell infiltrate.                                                                                                                                                                               ';
desc83 =  'Case 8 - Figure 3</font><br><font id=normaltext>There is a mid- and deep-dermal perivascular and interstitial mononuclear cell infiltrate.                                                                                                                                                                               ';
desc84 =  'Case 8 - Figure 4</font><br><font id=normaltext>The infiltrate comprises interstitial histiocytes associated with necrosis of collagen bundles.                                                                                                                                                                          ';
desc85 =  'Case 8 - Figure 5</font><br><font id=normaltext>The infiltrate comprises interstitial histiocytes associated with necrosis of collagen bundles.                                                                                                                                                                          ';
desc86 =  'Case 8 - Figure 6</font><br><font id=normaltext>The infiltrate comprises interstitial histiocytes associated with necrosis of collagen bundles.                                                                                                                                                                          ';
desc87 =  'Case 8 - Figure 7</font><br><font id=normaltext>The infiltrate comprises CD68-expressing histiocytes.                                                                                                                                                                                                                    ';
desc88 =  'Case 8 - Figure 8</font><br><font id=normaltext>There is IgG deposition in the dermis around collagen fibres.                                                                                                                                                                                                            ';
desc91 =  'Case 9 - Figure 1</font><br><font id=normaltext>There is psoriasiform hyperplasia of the epidermis with a pattern of abrupt epidermal keratinization, pallor and necrolysis.                                                                                                                                             ';
desc92 =  'Case 9 - Figure 2</font><br><font id=normaltext>There is psoriasiform hyperplasia of the epidermis with a pattern of abrupt epidermal keratinization, pallor and necrolysis.                                                                                                                                             ';
desca1 =  'Case 10 - Figure 1</font><br><font id=normaltext>There are confluent nodular histiocytic infiltrates in the mid and deep reticular dermis                                                                                                                                                                                 ';
desca2 =  'Case 10 - Figure 2</font><br><font id=normaltext>There is an irregular palisading granulomatous process involving the deep dermis; granulomas include giant cells with Touton forms as well as foam cells. Cholesterol clefts completed the picture (not illustrated).                                                    ';

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