/* Sequence of slide descriptions */
desc11 = 'Case 1 - Figure 1A
The punch biopsy of skin shows a heavy band like infiltrate of small, irregularly contoured lymphocytes embedded in coarse, horizontally-disposed collagen fibers. There is continuous haphazard epidermotropism suggesting patch/plaque mycosis fungoides ';
desc12 = 'Case 1 - Figure 1B
The punch biopsy of skin shows a heavy band like infiltrate of small, irregularly contoured lymphocytes embedded in coarse, horizontally-disposed collagen fibers. There is continuous haphazard epidermotropism suggesting patch/plaque mycosis fungoides ';
desc13 = 'Case 1 - Figure 1C
The punch biopsy of skin shows a heavy band like infiltrate of small, irregularly contoured lymphocytes embedded in coarse, horizontally-disposed collagen fibers. There is continuous haphazard epidermotropism suggesting patch/plaque mycosis fungoides ';
desc14 = 'Case 1 - Figure 2A
Both punch biopsy specimens show a band like infiltrate of small lymphocytes with a reduction on cell density over the orginal biopsy, in concert with discontinuous haphazard epidermal migration ';
desc15 = 'Case 1 - Figure 2B
Both punch biopsy specimens show a band like infiltrate of small lymphocytes with a reduction on cell density over the orginal biopsy, in concert with discontinuous haphazard epidermal migration ';
desc16 = 'Case 1 - Figure 3A
The punch biopsy specimens show a band like infiltrate of small lymphocytes with a directed pattern epidermal migration into an epidermis surmounted by parakeratotic mounds of plasma-containing scale crust. There is prominent involvement of the adnexal structures, which are sites of maximal antigenic processing. This is the classical pattern of lymphomatoid hypersensitivity ';
desc17 = 'Case 1 - Figure 3B
The punch biopsy specimens show a band like infiltrate of small lymphocytes with a directed pattern epidermal migration into an epidermis surmounted by parakeratotic mounds of plasma-containing scale crust. There is prominent involvement of the adnexal structures, which are sites of maximal antigenic processing. This is the classical pattern of lymphomatoid hypersensitivity ';
desc18 = 'Case 1 - Figure 4
Clinical examination shows no evidence of the rash at the truncal site of former maximal involvement ';
desc21 = 'Case 2 - Figure 1
There is a lichenoid infiltrate which is devoid of atypical lymphocytes. The epidermis shows mild hyperplasia ';
desc22 = 'Case 2 - Figure 2
The second biopsy shows marked epidermal hyperplasia and a sheet like dermal lymphoid intiltrate ';
desc23 = 'Case 2 - Figure 3
The keratinocytes are markedly atypical, as are large , non-cohesive cells in the dermis ';
desc24 = 'Case 2 - Figure 4
A cytokeratin immunostain (AE1/3) decorates the epidermis but spares the dermal infiltrate ';
desc25 = 'Case 2 - Figure 5
A CD30 immunostain strongly decorates the atypical dermal mononuclear cell infiltrate ';
desc26 = 'Case 2 - Figure 6
There is dot-like accentuation of CD30 expression in the Golgi region ';
desc27 = 'Case 2 - Figure 7
A CD20 preparation decorates background small lymphoid forms ';
desc28 = 'Case 2 - Figure 8
An anaplastic lymphoma kinase (ALK) preparation is negative ';
desc29 = 'Case 2 - Figure 9
A CD3 preparation strongly decorates small mature background T-cells; the larger cells show progressive loss of staining ';
desc31 = 'Case 3 - Figure 1
Violaceous skin nodule. ';
desc32 = 'Case 3 - Figure 2
A dense lymphoid infiltrate is present throughout the entire dermis. The epidermis is spared. ';
desc33 = 'Case 3 - Figure 3
Cytomorphology shows a monomorphous population of lymphoplasmacytoid cells admixed with marginal zone cells and some plasma cells. Intranuclear PAS+ inclusions (Dutcher bodies) could be detected in some of the cells. ';
desc41 = 'Case 4 - Figure 1
Eroded papules and small vesicles on the glans penis and prepuce ';
desc42 = 'Case 4 - Figure 2
There is an ulcerated, nodular infiltrate of mononuclear mid-sized cells, some with reniform nuclei located in the dermis with involvement of the epidermis by epidermotropic cells. Several mitoses could be seen. Immunohistochemical analyses showed positivity for S-100 and CD1a. A diagnosis of Langerhans cell histiocytosis was made, and a circumcision was performed ';
desc43 = 'Case 4 - Figure 3
There is an ulcerated, nodular infiltrate of mononuclear mid-sized cells, some with reniform nuclei located in the dermis with involvement of the epidermis by epidermotropic cells. Several mitoses could be seen. Immunohistochemical analyses showed positivity for S-100 and CD1a. A diagnosis of Langerhans cell histiocytosis was made, and a circumcision was performed ';
desc51 = 'Case 5 - Figure 1
There is a confluent proliferation of severely atypical plasmacytic cells associated with effacement of the dermal architecture ';
desc52 = 'Case 5 - Figure 2
There is a confluent proliferation of severely atypical plasmacytic cells associated with effacement of the dermal architecture ';
desc53 = 'Case 5 - Figure 3
Detection of EBV RNA by in situ hybridization. EBV RNA was detected in some of the tumor cells after in situ hybridization for EBER-1 and -2; note the strong nuclear signal ';
desc54 = 'Case 5 - Figure 4
Detection of HHV8 RNA by RT in situ PCR. HHV8 RNA was detected after in situ amplification of the corresponding cDNA using primers specific for the T0.7 viral message, which is expressed in latent and active infection. Note the strong nuclear signal in many of the tumor cells ';
desc61 = 'Case 6 - Figure 1
There is a diffuse and nodular pan dermal lymphocytic infiltrate associated with effacement of the dermal architecture ';
desc62 = 'Case 6 - Figure 2
Higher power magnification reveals that the cells have a large pleomorphic appearance. The cells are in the 20 micron size range manifesting prominent nucleoli. There was also perineural accentuation with focal endoneurial extension ';
desc63 = 'Case 6 - Figure 3
Phenotypic studies revealed that the infiltrate was a T cell showing CD8 positivity and weak CD20a nd CD10 expression ';
desc64 = 'Case 6 - Figure 4
A) GeneScanning image for TCR beta gene rearrangement shows a single distinct peak of 249 base pairs in size indicative of monoclonality with no evidence of a polyclonal background. B) GeneScanning image for IgH gene rearrangement shows two distinct peaks of 91 and 102 base pairs in size indicative of a dual clonal population (oligoclonal). C) Positive control ';
desc71 = 'Case 7 - Figure 1
Dense and diffuse dermal infiltrate with extension into the fat ';
desc73 = 'Case 7 - Figure 2
There is a grenz zone of papillary dermal sparing. ';
desc76 = 'Case 7 - Figure 3
The infiltrate is monotonous even at this power ';
desc77 = 'Case 7 - Figure 4
Large lymphocytes, some with features of immunoblasts, others with features of centroblasts. ';
desc74 = 'Case 7 - Figure 5
CD20. Staining with the CD20 antibody reveals a B-cell phenotype ';
desc72 = 'Case 7 - Figure 6
Large lymphocytes, some with features of immunoblasts, others with features of centroblasts. bcl-2: The tumor cells are strongly and uniformly bcl-2 positive ';
desc75 = 'Case 7 - Figure 7
Ki-67: The proliferative rate as measured by staining with Ki-67 is in excess of 80% ';
desc81 = 'Case 8 - Figure 1
Subcutaneous nodule on lower extremity ';
desc82 = 'Case 8 - Figure 2
Lobular lymphoid infiltrate ';
desc83 = 'Case 8 - Figure 3
For the most part the subcutaneous infiltrate is mixed. Few areas contain a monomorphous population ';
desc84 = 'Case 8 - Figure 4
A focally angiocentric growth pattern is present ';
desc85 = 'Case 8 - Figure 5
Rimming of fat cells by atypical lymphocytes ';
desc86 = 'Case 8 - Figure 6
"Bean bag cells". Macrophages with phagocytosed debris ';
desc87 = 'Case 8 - Figure 7
Mixed lobular infiltrate with pronounced angiocentricity ';
desc91 = 'Case 9 - Figure 1
There is a diffuse infiltrate in the dermis, with sparing of the epidermis ';
desc92 = 'Case 9 - Figure 2
The cells have an infiltrative growth pattern, and there is a Grenz zone ';
desc93 = 'Case 9 - Figure 3
The cells have finely distributed chromatin, and inconspicuous nucleoli ';
desc94 = 'Case 9 - Figure 4
The cells are positive for CD4. Staining is weaker than that of normal T-cells, which are focally seen ';
desc95 = 'Case 9 - Figure 5
CD56 is strongly positive in neoplastic cells, but negative in normal lymphocytes ';
desc96 = 'Case 9 - Figure 6
Neoplastic cells show nuclear staining for terminal deoxynucleotidyl transferase (TdT) ';
desc01 = 'Case 10 - Figure 1
A skin biopsy from 2001 shows infiltration of the dermis by atypical mast cells with a polygonal appearance ';
desc02 = 'Case 10 - Figure 2
The mast cells are strongly positive for tryptase by immunohistochemistry ';
desc03 = 'Case 10 - Figure 3
In 2004, following bone marrow transplantation, the patient developed a scalp mass. Deep dermis and subcutaneous tissues are infiltrated by large blastic cells. Rare eosinophilic myelocytes are identified ';
desc04 = 'Case 10 - Figure 4
The scalp mass also contains giant cells suggestive of megakaryocytes ';
desc05 = 'Case 10 - Figure 5
Many of the blastic cells are positive for chloroacetate esterase, but negative for myeloperoxidase (not shown) ';
desc06 = 'Case 10 - Figure 6
The megakaryocytes show staining for p-selectin ';
function parnav(imgnum)
{
parent.dir = '94th';
eval("parent.desc = desc"+imgnum);
eval("parent.slidenum = 'derm"+imgnum+"'");
slidepop();
return;
}
function winstatus(imgnum)
{
eval("window.status = desc"+imgnum+";");
return;
}