FORTY-EIGHTH MAUDE ABBOTT LECTURE

Tuesday, March 1, 2004 - 5:05 PM
Convention Center, Ballroom B

The Surgical Pathologist and the History of Breast Disease

David L. Page, M.D.



David Lee Page was born in New York City in 1941, the year mammary lobular carcinoma in situ was christened by Drs. Stewart and Foote of Memorial Hospital in the same city. His physician-father served in the Army Medical Corps in the South Pacific theater and in San Antonio (1942-1946) before moving the family to Dhahran, Saudi Arabia, in association with what is now SaudiAramco (1948 until 1959). Although attracted to medicine at an early age, David majored in history at Yale University, and found an abiding interest in surgical pathology while a student (fostered by William M. Shelley and William H. Hartmann) at Johns Hopkins Medical School. Following an internal medicine internship at Vanderbilt University Medical Center, the growing family (Lauren and children Emily and Robert) spent two years in Boston while David pursued Anatomic Pathology training at Massachusetts General Hospital in Boston (stimulated by Wally Clark, Robert Scully, Walter Putschar and Austin Vickery). This was followed by two years as a clinical and research fellow at the National Institutes of Health with George Glenner. After chief residency in anatomic pathology at Johns Hopkins, the Pages returned to Nashville, Tennessee, where Dr. Page has served in the Department of Pathology at Vanderbilt University, continuously directing Anatomic Pathology through most of that period until 1998. He became a Full Professor of Pathology in 1977 and Epidemiology in 1993. In 2000, he became adjuvant Professor of Pathology at the University of Arkansas Center for Medical Sciences.

There are two major themes in Dr. Page's professional career: education, particularly of surgical pathologists highlighting clinical relevance, and breast disease, emphasizing putative precursors. Published interests include breast, cardiac pathology and tumors of skin, liver and adrenal. The first publication in his CV is on Ecology and introduction of foreign species into new environments.

In the early 1970s, in association with William H. Hartmann and Lowell W. Rogers, Dr. Page developed a fellowship in surgical pathology at Vanderbilt University which includes clinical responsible interaction with all consultations and specimens received in Anatomic Pathology. Over 80 pathologists has finished this fellowship which was administered with Dr. George F. Gray for several years and is guided currently with Drs. Jim Atkinson, Kay Washington and Jean Simpson.

Travel to other academic centers is another central activity for Dr. Page. He has served as visiting professor in many countries around the world, including, Australia, Canada, Argentina, France, South Africa and Japan. He spent extended periods of teaching and research activities at the Pahlavi University in Shivaz, Iran and the University of Edinburgh, Scotland. Among keynote addresses delivered, the lecture at the 167th meeting of the Pathological Society of Great Britain and Northern Ireland stands out. Honorary degrees recognizing him as a distinguished visitor have been bestowed by the Universities of Tucuman and Cordoba in Argentina, Sendai University in Japan, and The American University of Beirut.

Dr. Page gave courses in breast pathology at the majority of the International Academy of Pathology meetings from 1984 in Miami through 2002 in the Netherlands. Short courses at the USCAP annual meeting include one in endocrine pathology with Lowell W. Rogers and one in breast pathology highlighting low malignancy lesions with Tom Anderson of the University of Edinburgh. The long courses of the ASCP and the USCAP were directed by Dr. Page in 1999 and 1997. Since the early 1980s, breast courses highlighting premalignancy of breasts and tumors of low malignant potential, has been given twice yearly with the ASCP along with Jean Simpson, Melinda Sanders and Roy Jensen. In 2000, he gave the Arthur Purdy Stout lecture at the ASCP meeting in Philadelphia.

In 1999, the Scientific Award of Distinction for Medical Research was bestowed on Dr. Page by the Susan G. Komen Foundation. The following year, the Stevensen Distinguished Service Award of the American Society of Clinical Pathologists was received by Dr. Page. In 2002 he received the Glen-Robbins Award for Breast Cancer Research of the New York Cancer Society and the New York Metropolitan Breast Cancer Group. At the 2003 European Institute of Oncology Breast Cancer meeting he received the 5th Therapy Award for "His outstanding contribution in unveiling the morphological predictors of breast cancer risk." In the same year, the Goodpasture Award of Vanderbilt University Medical School was shared with William Dupont for "collaborative studies that address important biological problems and their role in disease pathogenesis." Since 1974, this collaboration has produced continuous NCI and/or ACS funding, over 120 publications and a structure of classifications of breast lesions linked to epidemiologic studies with clinical relevance and endpoint verification. Their work has defined our understanding of breast cancer risk attributable to specific histologic factors.

Active involvement in many professional organizations has included leadership roles in the USCAP, ASCP, CAP, ADASP and the immediate past presidency of the Arthur Purdy Stout Society. Dr. Page currently serves as Chair of the American Joint Committee on Cancer.