/* Sequence of slide descriptions */
desc11 = 'Case 1 - Figure 1
An iliac crest biopsy demonstrates relatively uniform persistence of primitive woven bone with intervening fibrous marrow. Ineffective remodeling of bone is evident from the paucity of laminated osteoid and foci of mineralized matrix that resemble calcified cartilage. The density of hematopoietic cells in the marrow is markedly reduced ';
desc12 = 'Case 1 - Figure 2
At high magnification, numerous osteoclasts are easily identified along the surfaces of bony trabeculae. The surfaces of bone facing these multinucleate cells are flat, as opposed to the deep Howship lacunae that characterize normal osteoclast-mediated bone resorption ';
desc13 = 'Case 1 - Figure 3
A low magnification image of the core biopsy demonstrates the diffuse uniform nature of the underlying defect in osteoid resorption, reduced hematopoiesis, and marrow fibrosis ';
desc21 = 'Case 2 - Figure 1
The conjunctival connective tissue contains numerous fibroblasts distended by what appear by light microscopy to be empty vacuoles. This extensive cytoplasmic vacolization is very suggestive of a lysosomal storage disease. (Toluidine blue) ';
desc22 = 'Case 2 - Figure 2
By electron microscopy, the vacuoles distending the fibroblasts in the conjunctival stroma are surrounded by a single membrane and contain fine fibrillogranular storage material and occasional electron dense granules. This type of storage material is nonspecific but very characteristic of the mucopolysaccharidoses. It can also be seen in other lysosomal storage diseases, including mucolipidoses, mannosidosis, and sialadosis. (Uranyl acetate-lead citrate) ';
desc31 = 'Case 3 - Figure 1
Right kidney, bisected, illustrating a well demarcated multicystic mass with extension into adjacent renal calyces. The ureter is distended by similar tissue in its lumen. (Gross appearance) ';
desc32 = 'Case 3 - Figure 2
Right kidney. The cysts are lined by mature epithelium, ranging from tall "hobnail" cells with abundant cytoplasm to flattened, inconspicuous epithelial cells. The septa, while generally fibrous or fibromyxoid, focally are populated by condensations of round or elongated immature cells forming occasional tiny tubules. Occasional aggregates of lymphocytes and plasma cells are also present. (H&E, original magnification x 100) ';
desc33 = 'Case 3 - Figure 3
Right kidney. The polypoid projections of tissue into the calyces and ureter resemble the septal tissue but with a more myxoid and edematous interstitium. A cambium layer of condensed immature cells is focally present. The lining epithelium is mature and cuboidal to flat. (H&E, original magnification x 40) ';
desc34 = 'Case 3 - Figure 4
Right kidney. In one focus of the main mass, the interstitial cells assume bizarre anaplastic features, characterized by marked cellular pleomorphism, nuclear hyperchromasia, and very large multipolar or disorganized mitotic figures. Some of the anaplastic cells show cytoplasmic hyaline globules and karyorrhexis. The anaplastic cells, while focal, tend to infiltrate along the adjacent septa rather than impinging upon the cysts. Extensive further sampling revealed no additional anaplastic foci in the mass. (H&E, original magnification x 200)';
desc41 = 'Case 4 - Figure 1
Distal pancreas, peripancreatic tissue and spleen (gross) ';
desc42 = 'Case 4 - Figure 2
Pancreas with well-circumscribed partially cystic mass (gross) ';
desc43 = 'Case 4 - Figure 3
Pancreas mass exhibiting a variable growth pattern with solid and papillary areas (H & E stain) ';
desc44 = 'Case 4 - Figure 4
Pancreas mass solid areas composed of small uniform cells with eosinophilic cytoplasm, ovoid uniform nuclei with finely dispersed chromatin and inconspicuous nucleoli (H & E stain) ';
desc45 = 'Case 4 - Figure 5
Pancreas mass with papillary-appearing areas (H & E stain) ';
desc46 = 'Case 4 - Figure 6
Pancreas tumor cells strongly and uniform positive (Vimentin immunoperoxidase stain) ';
desc47 = 'Case 4 - Figure 7
Pancreas tumor cells exhibit positive nuclear staining (beta-catenin immunoperoxidase stain) ';
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