POSTER SESSION II Monday, February 28, 2005   —  1:00 - 4:30 PM Convention Center, Exhibit Hall B BREAST PATHOLOGY 11 The Effect of Trastuzumab (Herceptin®) Treatment on Estrogen Receptor Status in Patients with Early Stage HER2 Positive Breast Cancer (242) AK Witkiewicz, N Pliss, M Kamma, S Schnitt, HJ Burstein, L Harris - New York University Medical School, New York, NY; Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Harvard Medical School, Boston, MA 12 Cell Signaling Phospho-Proteins as a Targets of HER2/neu Activity and Prognosis in BreastCancer (212) F Rojo, L Najera, JL Lirola, S Rodriguez, J Jimenez, MD Sabadell, J Baselga, S Ramon y Cajal - Vall d'Hebron University Hospital, Barcelona, Spain 13 pAKT/PI3K Overexpression May Predict Poor Survival in Patients Treated with Herceptin for 3+ HER-2/neu Positive Breast Carcinoma (146) R Gupta, RStJ Ricketts, S Marconi, CN Otis - Baystate Medical Center/Tufts University School of Medicine, Springfield, MA 14 pAkt Expression Is Superior to HER-2/neu in Predicting Nodal Status in Breast Cancer (208) RStJ Ricketts, S Marconi, CN Otis - Baystate Medical Center/Tufts University School of Medicine, Springfield, MA 15 Clinical Significance of Chromosome 17 Polyploidy in Patients with Breast Cancer (180) JR McEvoy, FM Cady, JS Metcalf, DJ Wolff - Medical University of South Carolina, Charleston, SC 16 HER-2/neu Gene, Chromosome 17 Aberrations and Invasive Ductal Carcinoma: A Comparative Study between Young and Old Age Women (139) RR Fonseca, A Tomás, S André, J Soares - Instituto PortuguLs Oncologia Francisco Gentil CROL SA, Lisboa, Portugal 17 Immunohistochemical Analysis of HER-2 in Tumors Showing an Increased Number of HER-2 Genes but a HER-2:CEP-17 Ratio of Less Than 2 (167) AJ Kyshtoobayeva, KJ Bloom - ChromaVision Medical Systems, Irvine, CA 18 Pathology of the Borderline HER-2/neu Breast Carcinoma (159) JL Killeen, A Ortega-Lopez, JB Fu - Kapiolani Medical Center for Women and Children, Honolulu, HI 19 Frequency of Indeterminate HER-2/Neu Staining and Gene Amplification in Ductal and Lobular Carcinoma: A Comparative Study (249) L Zhang, H Alatassi, AW Martin, S Sahoo - University of Louisville, Louisville, KY 20 Her2/neu FISH Amplification in Negative Immunohistochemistry Scored Breast Carcinomas (126) SA Dayan, JF Silverman, YL Liu, CA Smith, SE Shackney - Allegheny General Hospital, Pittsburgh, PA 21 Differences in the Rate of Her-2/neu Gene Amplification in Cases Reflexed from Immunohistochemistry Performed by Manual Review Versus Image Analysis (135) FJ Espinoza, AJ Kystoobayeva, KJ Bloom - ChromaVision Medical Systems, Irvine, CA 22 EnzMet GenePro, a Novel Bright Field Assay that Simultaneously Profiles HER-2 Genotype and Phenotype, Correlates with Overall and Disease Free Survival of Breast Cancer (247) BJ Yoder, T Choueiri, E Downs-Kelly, M Skacel, J Hainfeld, R Powell, P Roche, T Grogan, J Pettay, T Budd, DG Hicks, RR Tubbs - The Cleveland Clinic Foundation, Cleveland, OH; Nanoprobes, Yaphank, NY; Ventana Medical Systems, Tucson, AZ 23 Analysis of HER-2 Gene Amplification Using an Automated FISH Signal Enumeration System (223) R Stevens, I Almanaseer, M Gonzalez, D Caglar, RA Knudson, RP Ketterling, JA Bridge - University of Nebraska Medical Center, Omaha, NE; Advocate Lutheran General Hospital, Park Ridge, IL; Mayo Clinic, Rochester, MN 24 Distribution of FISH Scores in Amplified Breast Carcinomas Derived from 9546 Consecutive Cases (109) KJ Bloom, D Helling, D Bouman - ChromaVision Medical Systems, Irvine, CA; US Labs, Irvine, CA 25 HER 2 Protein Overexpression and Gene Amplification in Breast Cancer: A Comparison of Immunohistochemistry and Fluorescent and Chromogenic In Situ Hybridization (214) A Sáez, FJ Andreu, S Fernández, MA Seguí, M Rey - UDIAT-Centre Diagnbstic - Corporació Parc Taulí, Sabadell, Barcelona, Spain; Corporació Parc Taulí, Sabadell, Barcelona, Spain 26 Chromogenic In Situ Hybridization (CISH), a Helpful Tool for the Pathologist To Identify HER2/NEU Amplification in Breast Carcinomas. Comparative Study with IHC and FISH (173) EML Li Ning, R Ronchetti, CA Torres-Cabala, LS Teller, MJ Merino - NCI/NIH, Bethesda, MD 27 Correlation of Her2/Neu Testing Using Chromogenic In Situ Hybridization (CISH) with Immunohistochemistry (IHC) and Fluorescence In Situ Hybridization (FISH) in Breast Cancer (147) WM Hanna, K Kwok - Sunnybrook & Women's College Health Sciences Centre, University of Toronto 28 Evaluation of HER-2/neu Status in Breast Carcinomas: A Combined Approach Including FISH, CISH, Real Time QRT PCR and Immunohistochemistry (162) E Kostopoulou, D Kaisaridou, M Ioannou, N Vladica, M Nakou, G Kalodimos, M Netsika, G Koukoulis - University of Thessaly, Larissa, Greece 29 CISH with a Centromeric Probe for Chromosome 17 Can Be as Accurate as FISH in Detecting Polysomy in Breast Carcinomas (161) E Kostopoulou, M Ioannou, M Nakou, G Kalodimos, M Netsika, G Koukoulis - University of Thessaly, Larissa, Greece 30 HER-2 and Topoisomerase II-alpha Gene Amplification and Protein Overexpression in Invasive Breast Cancer: Chromogenic In Situ Hybridization and Immunohistochemical Analyses (105) R Bhargava, P Lal, B Chen - Memorial Sloan-Kettering Cancer Center, New York, NY 31 Expression of Cyclooxygenase-2 in Breast Carcinogenesis and Its Relation to p53 and HER-2/neu Protein Expression in Invasive Ductal Carcinoma (170) JS Lee, HJ Kim, JH Lee, JH Nam, C Choi, MC Lee, CS Park, SW Juhng, JH Yoon, KW Min - Chonnam National University Medical School, Gwangju, Republic of Korea; Deaconess Hospital, Oklahoma City, OK 32 Comparative Analysis of Her2/Neu Status with Histopathologic Parameters and Hormone Receptor (HR) Status in Breast Carcinomas (Ca) (160) JW Kim, MJ Kim, J Choi, GY Gong, JY Ro - University of Ulsan College of Medicine, Seoul, Korea 33 Epidermal Growth Factor Receptor (EGFR) Gene Amplification and Protein Expression in Breast Carcinoma: A Study of 175 Tumors (106) R Bhargava, P Lal, W Gerald, B Chen - Memorial Sloan-Kettering Cancer Center, New York, NY 34 Epidermal Growth Factor Receptor (EGFR) Expression in High Grade Invasive Mammary Carcinoma (200) ML Policarpio-Nicolas, KT Schafernak, LK Diaz, N Kidwai, EL Wiley - Feinberg School of Medicine Northwestern University, Chicago, IL 35 Evaluation of Epidermal Growth Factor Receptor (EGFR) and Estrogen Receptor (ER) in Primary Breast Cancers and Lymph Node Metastases Using Tissue Microarray (108) C Bicquart, K Kawase, MKP Garcia, D Rosen, WF Symmans, J Liu, CT Albarracin - Univ of Texas, M. D. Anderson Cancer Center, Houston, TX