This course will discuss the use of immunohistochemistry as an adjunct to histologic evaluation in female genital tract pathology. The differential diagnosis of common and difficult gynecologic lesions will be organized by site to include: pagetoid lesions of the vulva; squamous intraepithelial lesions of the lower genital tract; cervical and endometrial adenocarcinomas; atypical endometrial surface proliferations; stromal tumors versus smooth muscle tumors of the uterus; uterine sarcomas; ovarian carcinoma versus mesothelioma; ovarian surface-epithelial tumors versus metastatic lesions; ovarian surface-epithelial tumors versus sex cord-stromal and germ cell tumors; and the differential diagnosis of ovarian small round cell tumors.

Trainees and general pathologists will benefit most from this course. Educational objectives include understanding the applications and limitations of immunohistochemistry in diagnostic gynecologic pathology. More specifically, we anticipate that the participants will be able to effectively use the following antibodies in narrowing the differential diagnosis of the entities listed above: Ki-67, ER, PR, p53, desmin, CD10, h-caldesmon, inhibin, hPL, hCG, AFP, CD117, calretinin, cytokeratins 5/6, 7, and 20, S100, HMB45, Melan-A, TTF-1, EMA, CD45, and CD30. A limited number of loan sets of glass slides and transparencies will be available for advance mailing. All registrants for the course will receive a set of transparencies after the meeting. A detailed syllabus will be distributed at the course. (Last Scheduled Presentation)