Submitted by: Michael J. Klein University of Alabama Medical Center Birmingham, AL
A seventeen year old male presented with a three month history of increasing thigh and knee pain. The
pain was localized to his medial thigh and knee and was felt both at rest and during exercise. It
interfered significantly with his daily activities of living.
Physical examination revealed an area of tenderness and a sensation of fullness in his medial knee.
There was some stiffness in the joint and slight limitation in flexion.
Following clinical imaging studies, he was taken to the operating room where he underwent open biopsy
followed by a second procedure six days later.
Submitted by: Pancras C. W. Hogendoorn Leiden University Medical Center Leiden, Netherlands
A 29-YOF presents with pain in the lower back, extending into the right leg. There is neither a
relation of the pain with coughing nor with position of the vertebral column. Medical and family history
are unremarkable. Neurovascular no abnormalities. Normal routine blood laboratory findings. The
physical examination showed no swelling palpable; pain upon deep palpation of the dorsal back at the
right sacro-iliac area. Bone scan shows a solitary lesion of the right ilium wing with only minimal-mild
Submitted by: A. Kevin Raymond MD Anderson Cancer Center Houston, TX
A 53-year old man presented with a 3-month history of numbness and tingling involving the left
maxillary gingival. He also indicates that he has a sense of "prominent tissue" over the left palate."
Imaging studies show a mixed lytic/blastic lesions involving the left maxilla. His medical history is
significant for nasopharyngeal carcinoma treated some 25 years ago by radiation therapy.