/* Sequence of slide descriptions */
desc11 = 'Case 1 - Figure 1
Low power photomicrograph of right axillary lymph node (H&E) ';
desc12 = 'Case 1 - Figure 2
Intermediate power - right axillary lymph node (H&E) ';
desc13 = 'Case 1 - Figure 3
High power medullary region of right axillary lymph node (H&E) ';
desc14 = 'Case 1 - Figure 4
Peripheral blood smear (Wright\'s) ';
desc15 = 'Case 1 - Figure 5
Low power photomicrograph of bone marrow core biopsy (H&E) ';
desc16 = 'Case 1 - Figure 6
Intermediate power photomicrograph of bone marrow core biopsy (H&E) ';
desc17 = 'Case 1 - Figure 7
High power photomicrograph of bone marrow core biopsy (H&E) ';
desc18 = 'Case 1 - Figure 8
Bone marrow core biopsy (reticulin) ';
desc21 = 'Case 2 - Figure 1
Review of a the peripheral blood smear reveals the majority of the lymphocytes to have small nuclei and relatively abundant cytoplasm containing variably prominent granules ';
desc22 = 'Case 2 - Figure 2
The bone marrow biopsy is normocellular to slightly hypercellular with decreased erythropoesis, increased granulopoesis, and unremarkable megakaryopoesis. The most evident lymphoid element on morphologic review are the bland appearing interstitial lymphoid aggregates ';
desc23 = 'Case 2 - Figure 3
Immunoperoxidase staining of the bone marrow biopsy reveals the interstitial lymphoid aggregates to predominantly contain CD3 positive T-cells (left) with lesser numbers of CD20 positive B-cells (right) ';
desc24 = 'Case 2 - Figure 4
Additional immunoperoxidase stains demonstrate that the CD3 positive T-cells (left) in the lymphoid aggregates do not express the cytotoxic granule protein granzyme B (right). Note the presence of small granzyme B positive cells at the periphery of the lymphoid aggregate ';
desc25 = 'Case 2 - Figure 5
Increased numbers of CD3 positive T-cells were present in the marrow interstitium (stain not shown). These interstitial T-cells are CD8 positive, with clusters of CD8 positive cells present ';
desc26 = 'Case 2 - Figure 6
On closer examination a linear of distribution of CD8 positive cells in the bone marrow biopsy is evident. This is attributable to the presence of these cells in small vessels ';
desc27 = 'Case 2 - Figure 7
The intravascular T-cells are also positive for the cytotoxic granule proteins TIA-1 (top) and granzyme B (bottom) ';
desc28 = 'Case 2 - Figure 8
Flow cytometric immunophenotyping analysis performed on the bone marrow aspirate reveals the presence of an immunophenotypically aberrant T-cell population with diminished expression of CD3 and CD7 (right, indicated by arrow). Subsets of these cells show both diminished expression and complete loss of CD5 (left, arrows) ';
desc29 = 'Case 2 - Figure 9
Flow cytometry demonstrates the T-cells to be CD8 positive (left, arrow). These cells aberrantly coexpress CD16 (right, arrow) ';
desc2a = 'Case 2 - Figure 10
3-color flow cytometry allows for selective gating on the CD3 and CD16 positive T-cells (left, cells are in gate R2 and highlighted green). This technique is used to confirm that these cells coexpress CD57 (right) ';
desc2b = 'Case 2 - Figure 11
The same gating strategy used in Figure 10 is used to demonstrate that the CD3 and CD16 positive cells show uniform expression of the KIR antigen CD158b. These cells do not express CD158a or CD158e (also known as p70) ';
desc31 = 'Case 3 - Figure 1
Bone marrow aspirate (Wight-Giemsa) showing marrow elements and clusters of mast cells ';
desc32 = 'Case 3 - Figure 2
Bone marrow aspirate (Wight-Giemsa) showing marrow elements and clusters of mast cells (100x oil) ';
desc33 = 'Case 3 - Figure 3
Bone marrow aspirate (Wight-Giemsa) containing several clusters of abnormal myeloid/monocytic precursors and some with dysgranulation and marked left-shift (blasts ~ 8%) ';
desc34 = 'Case 3 - Figure 4
Bone marrow aspirate (Wight-Giemsa) showing focus of immature myeloid cells / left-shift ';
desc35 = 'Case 3 - Figure 5
Bone marrow biopsy was hypercellular (85-90%) cellular and contained mixtures of early and large hematopoietic elements in varying stages of maturation. Also, are found several collections of mast cells with central round pale nuclei and pale granular cytoplasm ';
desc36 = 'Case 3 - Figure 6
Bone marrow biopsy (20x Obj) shows mild para-trabecular fibrosis and mast cells / hematopoietic elements ';
desc37 = 'Case 3 - Figure 7
Immunohistochemical stain CD117 (c-kit) was positive in most of mast cells (10x Obj) ';
desc38 = 'Case 3 - Figure 8
Immunohistochemical stain CD117 (k-kit) was positive in most of mast cells. High power examination (40x Obj) confirms that most are mast cells with strong membrane / cytoplasmic staining and pale nuclei. Rare myeloid precursors are staining ';
desc39 = 'Case 3 - Figure 9
Immunochemical stain tryptase was positive in few of the mast cells ';
desc41 = 'Case 4 - Figure 1
Prefibrotic CIMF. Peripheral blood smear showing increased platelets, mild leukocytosis due to neutrophilia, and occasional teardrop-shaped red blood cells ';
desc42 = 'Case 4 - Figure 2
Prefibrotic CIMF. Representative fields from the peripheral blood smear showing segmented neutrophils with normal morphology, occasional myelocytes, and basophils. In these fields there is minimal red blood cell poikilocytosis ';
desc43 = 'Case 4 - Figure 3
Prefibrotic CIMF. Representative fields of the bone marrow biopsy demonstrate megakaryocytic proliferation, with the megakaryocytes in clusters ';
desc44 = 'Case 4 - Figure 4
Prefibrotic CIMF. Representative fields of the bone marrow biopsy demonstrate megakaryocytic proliferation, with the megakaryocytes in clusters ';
desc45 = 'Case 4 - Figure 5
Prefibrotic CIMF. High power fields of the biopsy demonstrate the variable size and atypia of the megakaryocytes. Naked megakaryocyte nuclei are seen, and in some the N:C ratio is abnormal. There is marked neutrophil proliferation but diminished numbers of erythroid precursors ';
desc46 = 'Case 4 - Figure 6
Prefibrotic CIMF. The aspirate smear is poorly cellular and cytology was not well preserved. The reticulin stain reveals only minimal increase in reticulin fibers ';
desc47 = 'Case 4 - Figure 7
Prefibrotic CIMF. The aspirate smear is poorly cellular and cytology was not well preserved. The reticulin stain reveals only minimal increase in reticulin fibers ';
desc48 = 'Case 4 - Figure 8
Prefibrotic CIMF. This figure summarizes the important findings, including the thrombocytosis in the blood, the hypercellular bone marrow biopsy with predominantly granulocytic and megakaryocytic proliferation, and the atypia of the megakaryocytes. There is a minimal increase in reticulin fibers ';
function parnav(imgnum)
{
parent.dir = '95th';
eval("parent.desc = desc"+imgnum);
eval("parent.slidenum = 'hema"+imgnum+"'");
slidepop();
return;
}
function winstatus(imgnum)
{
eval("window.status = desc"+imgnum+";");
return;
}