Recent Developments in Diagnostic and Therapeutic Approaches to Breast Diseases
Daniel W. Visscher, M.D.
Carol Reynolds, M.D.
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This stereotactic core needle biopsy specimen is from a 57 year old woman with mammographically-detected microcalcifications. Is an open biopsy necessary?
This stereotactic core needle biopsy specimen is from a 62 year old woman with new mammographically-detected microcalcifications. What is your recommendation?
This ultrasound-guided core needle biopsy specimen is from a 38 year old woman with a well-circumscribed solid mass by imaging. How would you report the findings and what is your recommendation?
This core needle biopsy specimen was performed in a 52 year old woman with a subareolar mass. Ultrasound showed a solid, homogenously hypoechoic mass. What is your diagnosis? What is your recommendation?
This specimen is from a 53 year old woman. What was the most likely mammographic abnormality that prompted this core needle biopsy?
This stereotactic core needle biopsy specimen is from a 42 year old with mammographically-detected microcalcifications. What is your recommendation?
This 55 year old woman had undergone prior core needle biopsy that showed an “atypical papillary intraductal proliferation, suspicious for DCIS.” The subsequent excision showed DCIS arising in association with a papilloma. How would you interpret the cellular focus that was adjacent to a duct that contained DCIS?
This is an excisional biopsy from a 63-year-old woman with extensive ductal carcinoma in situ measuring 3.0 cm in greatest extent. In two microscopic fields the following changes were identified. What is the appropriate staging classification for this lesion? What is the clinical significance?
This is a 2.3 cm breast mass from a 61-year-old woman. Nine axillary lymph nodes were positive for metastatic carcinoma. How would you classify this lesion?
This is a 56-year-old woman with mammographic density. What is your differential diagnosis? What additional studies would be appropriate to further classify this lesion?
This specimen is from a 78-year-old woman with unilateral nipple discharge. An open biopsy was performed. What is your diagnosis?
This sentinel lymph node is from a 49 year old woman with 2.2 cm infiltrating lobular carcinoma. The sentinel lymph node was reported as “negative” at the time of intra-operative examination.
How would you score this Her-2/neu stain? What is the likelihood that this neoplasm has Her-2/neu amplification?