Clinical History
45 year old with 4 year history of hemodialysis secondary to end-stage renal disease secondary to diabetes mellitus. Now with thickened, somewhat rigid extremities (more on lower), rule out scleroderma.
Case 2 - Figure 1 -
Fibrous septa between subcutaneous fat lobules are greatly expanded.
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Case 2 - Figure 2 -
Higher magnification demonstrates an accumulation of spindle shaped cells.
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Case 2 - Figure 3 -
The spindle shaped cells course in a stroma that has increased mucin as well as fibrotic changes.
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References
- Kucher C, Xu X, Pasha T, Elenitsas R. Histopathologic comparison of nephrogenic fibrosing dermopathy and scleromyxedema. J Cutan Pathol. 2005 Aug;32(7):484-90.
- LeBoit PE. What nephrogenic fibrosing dermopathy might be. Arch Dermatol. 2003 Jul;139(7):928-30. No abstract available.
- Cowper SE, Su LD, Bhawan J, Robin HS, LeBoit PE. Nephrogenic fibrosing dermopathy. Am J Dermatopathol. 2001 Oct;23(5):383-93.
