Case 1 Submitted by: Michelle S. Hirsch Brigham and Women’s Hospital Boston, MA Clinical Summary: A 78 year-old G6P6 female with a past medical history of chronic lymphocytic leukemia presents with vulvar irritation and a pigmented vulvar mass. Biopsy confirmed the diagnosis of malignant melanoma. Peripheral to the main mass the vulva grossly appeared reddened, and the perineum appeared white and thickened. Multiple radial biopsies were taken to determine the extent of involvement by melanoma. Subsequently, a radical vulvectomy was performed. Five months after the radical vulvectomy the patient developed bilateral groin adenopathy. Case 1 - Figure 1 Biopsy of Pigmented Vulvar Mass Case 1 - Figure 2 Mapping biopsy Case 1 - Figure 3 Mapping biopsy Case 1 - Figure 4 Mapping biopsy Case 1 - Figure 5 Resected Specimen Case 1 - Figure 6 Histology of Resected Specimen Case 2 Submitted by: Robert A. Soslow Memorial Sloan-kettering Cancer Center New York, NY Clinical Summary: The patient is a 44 year-old woman diagnosed with ovarian serous carcinoma 12 years ago. She underwent unilateral salpingo-oophorectomy followed by treatment with multi-agent chemotherapy. She subsequently suffered 2 recurrences, 5 and 7 years after diagnoses, and has had persistent disease for the past 5 years. She has recently undergone resection of a pre-sacral mass. Case 2 - Figure 1 Primary Tumor Case 2 - Figure 2 Recurrence Case 2 - Figure 3 Recurrence Case 2 - Figure 4 Recurrence Case 2 - Figure 5 Recurrence Case 3 Submitted by: Kristen A. Atkins University of Virginia Health Science Center Charlottesville, VA Clinical Summary: A 25 year old healthy Caucasian woman had an intramucosal uterine myoma resulting in two miscarriages. An endometrial curettage was performed followed by a myomectomy. The images are from the myomectomy and include an immunostain for Ki-67 activity(MIB-1). Case 3 - Figure 1 Case 3 - Figure 2 Case 3 - Figure 3 Case 3 - Figure 4 Case 3 - Figure 5 Case 3 - Figure 6 Case 3 - Figure 7 MIB-1 Immunostain Case 4 Submitted by: Russell Vang Johns Hopkins Medical Institutions Baltimore, MD Clinical Summary: The patient is an 89 year-old who presented with massive mucinous ascites. A 15 cm ruptured multiloculated left ovarian tumor was found. Surgical exploration, bilateral salpingo-oophorectomy, partial omentectomy, and appendectomy were performed. The entire appendix was examined histologically and was normal. Case 4 - Figure 1 Case 4 - Figure 2 Case 4 - Figure 3 Case 4 - Figure 4 Case 4 - Figure 5 Case 4 - Figure 6 Case 4 - Figure 7 Case 4 - Figure 8 Case 4 - Figure 9 Case 4 - Figure 10 Case 4 - Figure 11 CK7 Case 4 - Figure 12 CK20 Case 5 Submitted by: Christopher P. Crum Brigham & Women’s Hospital Boston, MA Clinical Summary: A 60 year old woman presented with a history of pelvic discomfort. Physical exam disclosed a large pelvic-abdominal mass. Laparotomy was performed, with bilateral salpingo-oophorectomy, segmental bowel resection, omentectomy and subtotal removal of the tumor. Case 5 - Figure 1 Ovary Case 5 - Figure 2 Fallopian Tube Case 5 - Figure 3 Fallopian Tube Serosa Case 5 - Figure 4 Omentum Case 5 - Figure 5 Uterus Case 5 - Figure 6 Lymph Node Case 5 - Figure 7 Lymph Node

Please Note -
Prior to this Annual Meeting, slides and case histories for each of the Specialty Conferences will be posted on this website (www.uscap.org) so they may be reviewed in advance. During the meeting the slides and protocols will be available for study in the microscope room (Chicago B - F Room) for participants who wished to review them prior to the evening session.

Handouts for all Specialty Conferences will be available on the website the morning after the conference. Printed copies of the handout will not be available at the meeting. However, we will provide a booklet at the meeting which will have a page for each Specialty Conference, listing the names of speakers and having ample space for writing the important “take home messages”.