Gynecologic Pathology
Wednesday, February 15, 2006 - 7:30 PM
Centennial III, IV
Moderator:
Christopher P. Crum Brigham & Women's Hospital Boston, MA
Disclosure: The speakers have indicated they have nothing to disclose.
Clinical histories are printed below.
Click on the case numbers for text and references of each case.
Click on each slide thumbnail image for an enlarged view
Case 1
Submitted by: Michelle S. Hirsch Brigham and Women’s Hospital Boston, MA
Clinical Summary:
A 78 year-old G6P6 female with a past medical history of chronic lymphocytic leukemia presents with vulvar irritation and a pigmented vulvar mass. Biopsy confirmed the diagnosis of malignant melanoma. Peripheral to the main mass the vulva grossly appeared reddened, and the perineum appeared white and thickened. Multiple radial biopsies were taken to determine the extent of involvement by melanoma. Subsequently, a radical vulvectomy was performed. Five months after the radical vulvectomy the patient developed bilateral groin adenopathy.
Case 2
Submitted by: Robert A. Soslow Memorial Sloan-kettering Cancer Center New York, NY
Clinical Summary:
The patient is a 44 year-old woman diagnosed with ovarian serous carcinoma 12 years ago. She underwent unilateral salpingo-oophorectomy followed by treatment with multi-agent chemotherapy. She subsequently suffered 2 recurrences, 5 and 7 years after diagnoses, and has had persistent disease for the past 5 years. She has recently undergone resection of a pre-sacral mass.
Case 3
Submitted by: Kristen A. Atkins University of Virginia Health Science Center Charlottesville, VA
Clinical Summary:
A 25 year old healthy Caucasian woman had an intramucosal uterine myoma resulting in two miscarriages. An endometrial curettage was performed followed by a myomectomy. The images are from the myomectomy and include an immunostain for Ki-67 activity(MIB-1).
Case 4
Submitted by: Russell Vang Johns Hopkins Medical Institutions Baltimore, MD
Clinical Summary:
The patient is an 89 year-old who presented with massive mucinous ascites. A 15 cm ruptured multiloculated left ovarian tumor was found. Surgical exploration, bilateral salpingo-oophorectomy, partial omentectomy, and appendectomy were performed. The entire appendix was examined histologically and was normal.
Case 5
Submitted by: Christopher P. Crum Brigham & Women’s Hospital Boston, MA
Clinical Summary:
A 60 year old woman presented with a history of pelvic discomfort. Physical exam disclosed a large pelvic-abdominal mass. Laparotomy was performed, with bilateral salpingo-oophorectomy, segmental bowel resection, omentectomy and subtotal removal of the tumor.
