PROFFERED PAPERS
Tuesday, March 27   —  8:00 AM   —  CC 1 A/B


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Section C - GASTROINTESTINAL PATHOLOGY
Chaired by: Joel Greenson and Wade Samowitz



TimeTitle and AuthorsItinerary
Planner
8:00 Instability of EGFR Gene Status during Progression of Colorectal Cancer (502)
G De Hertogh, N Personeni, M Debiec-Rychter, J De Schutter, P Van Eyken, K Geboes, E Van Cutsem, S Tejpar - University Hospitals KULeuven, Leuven, Vlaams-Brabant, Belgium
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8:15 High Frequency of Platelet Derived Growth Factor Receptor Alpha Mutations in Gastrointestinal Stromal Tumors: Detection by High Resolution Melting Amplicon Analysis (524)
JA Holden, C Willmore-Payne, D Coppola, CR Garrett, LJ Layfield University of Utah Health Sciences Center, Salt Lake City, UT; H. Lee Moffitt Cancer and Research Institute, Tampa, FL
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8:30 Immunohistochemical Staining for CDX-2, PDX-1, NESP-55, and TTF-1 Can Help Distinguish Gastrointestinal Carcinoid Tumors from Pancreatic Endocrine and Pulmonary Carcinoid Tumors (587)
A Srivastava, JL Hornick Dartmouth-Hitchcock Medical Center, Lebanon, NH; Brigham and Women's Hospital, Boston, MA
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8:45 Fatty Acid Synthase Overexpression in Colorectal Cancer Is Associated with Microsatellite Instability, Independent of CpG Island Methylator Phenotype (CIMP) (534)
T Kawasaki, CS Fuchs, M Loda, S Ogino Dana-Farber Cancer Inst, Boston, MA; Brigham and Women's Hosp, Boston, MA; Harvard Medical School, Boston, MA
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9:00 Differential Gene Expression Profiling of MGMT Deficient Colorectal Cancer Reveals a Carcinogenic Pathway Distinct from Other Mismatch Repair Intact Tumors (478)
GP Bailey, BS Wittner, S Ramaswamy, MS Redston Brigham and Women's Hospital, Boston, MA; Massachusetts General Hospital, Boston, MA
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9:15 MSI-High CIMP-High Colorectal Cancers Show Frequent Down-Regulation of Nuclear p27 (CDKN1B), While Non-MSI Non-CIMP-High Tumors Show Frequent Down-Regulation of p21 (CDKN1A) (562)
S Ogino, T Kawasaki, GJ Kirkner, A Ogawa, M Loda, CS Fuchs Brigham and Women's Hospital, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; Harvard Medical School, Boston, MA
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9:30 RECESS, EXHIBITS, POSTER SESSION III
Coffee Break sponsored by PathSync
 
11:00 Interobserver Variability in the Diagnosis of Hyperplastic and Serrated Colonic Polyps (561)
RD Odze, K Batts, N Goldstein, S Hamilton, J Jass, M O'Brien, R Riddell, D Snover, H Wang Brigham and Womens Hospital, Boston, MA; Abbott Northwestern Hospital, MN; William Beaumont Hospital, MI; Univ. Texas MD Anderson, TX; McGill Univ, Canada; Boston Medical Center, MA; Mt. Sinai Hospital, Canada; Fairview Southdale Hospital, MN; Beth Israel Deaconess Medical Center, MA
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11:15 Serrated Adenomas of the Large Intestine: Loss of Crypt Anchoring Is a Defining Feature of Traditional Versus Sessile Serrated Adenomas (590)
EE Torlakovic, JD Gomez, T Banerjee, C Wang, Z Gatalica, DC Snover Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada; Creighton University Medical Center, Omaha, NE; Fairview Southdale Hospital, Edina, MN
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11:30 A Distinct Spectrum of Pathology Is Associated with KRAS Mutations in the Serrated Polyp Neoplasia Pathway (576)
J Robbins, S Yang, H Xu, C Shepherd, B Burke, C Mark, C Huang, FA Farraye, MJ O'Brien Bost.Univ.Sch.Med, Boston, MA; BMC, Boston, MA
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11:45 Prevalence and Clinical Significance of Serrated Lesions in Ulcerative Colitis (489)
VS Chandan, M Garrity, SC Abraham, TC Smyrk Mayo Clinic, Rochester, MN
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