|
Dermatopathology
Monday, March 26, 2007, 7:30 PM
CC 5 A/BNeoplasms of the Epidermis
|
Moderator:
BRUCE R. SMOLLER
University of Arkansas for Medical Sciences
Little Rock, AR
Disclosure: The speakers have indicated they have nothing to disclose.
|
Clinical histories and Virtual Slides as well as Still Images are displayed below.
For the fastest viewing of virtual slides, click:
under each thumbnail image below. You must have Aperio ImageScope installed on your PC.
|
If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy: | 
|
Or, click on slide thumbnail images to view each slide
in a Web-based slide viewer, which is somewhat slower.
If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137.
for Text and References
Submitted by: David Cassarino - Stanford University School of Medicine, Stanford, CA
A 60 year-old male presented with a several month history of an enlarging, occasionally bleeding, lesion on his scalp. Clinical examination showed a 1.5 cm ulcerated plaque on the left scalp; the clinical differential diagnosis was SCC versus BCC.
Case 1 - Slide 1
|
Case 1 - Figure 1
Scalp tumor with deep dermal invasion, 2X
|
Case 1 - Figure 2
Infiltrating tumor with basaloid to squamoid differentiation and clear cell areas, 4X
|
Case 1 - Figure 3
Higher power of squamoid-appearing area with scattered large, pleomorphic clear cells (arrow), 20X
|
for Text and References
Submitted by: David Cassarino - Stanford University School of Medicine, Stanford, CA
A 54 year-old female presented with a several-year history of a lesion on her buttock. Clinical examination showed a 2 cm, firm, bluish nodule on the left buttock. The clinical impression was pilomatricoma versus other adnexal neoplasm.
Case 2 - Slide 1
|
for Text and References
Submitted by: Kim Hiatt - University of Arkansas for Medical Sciences, Little Rock, AR
A 59 year old man presented with a nodule in the left pre-auricular area. He has no significant medical history.
Case 3 - Slide 1
|
Case 3 - Figure 1
This low power image shows an endophytic lobular neoplasm extending into the dermis from a hair follicle.
|
Case 3 - Figure 2
This high power image is representative of the entire tumor mass, showing large polygonal cells, pleomorphic nuclei, numerous mitosis and tissue invasion.
|
for Text and References
Submitted by: Kim Hiatt - University of Arkansas for Medical Sciences, Little Rock, AR
A 43 year old female presented with an asymptomatic nodule on the nose. She is otherwise healthy.
Case 4 - Slide 1
|
Case 4 - Figure 1
This low power image show a demal neoplasm composed of lobules of basaloid cells set in a dense collagenous stroma.
|
Case 4 - Figure 2
This high power image highlights peripheral palisading of the nests of basaloid cells and the dense surrounding stroma. Additionally noted is a moderate infiltrate of small mature lymphoctes within the tumor nests.
|
for Text and References
Submitted by: Steve Billings - University of Indiana School of Medicine, Indianapolis, IN
A 73-year old man presented to his dermatologist with an 10 mm
flesh-colored papule on his scalp.
Case 5 - Slide 1
|
Case 5 - Figure 1
Low power examination demonstrated a spindle cell tumor permeating the entire dermis.
|
Case 5 - Figure 2
No apparent attachment to the overlying epidermis was apparent.
|
Case 5 - Figure 3
The tumor was composed of pleomorphic, hyperchromatic spindled cells.
|
Case 5 - Figure 4
There was a prominent desmoplastic response to the invasive tumor.
|
for Text and References
Submitted by: Steve Billings - University of Indiana School of Medicine, Indianapolis, IN
A 68-year old woman presented with a flesh-colored to slightly
erythematous papule on her face.
Case 6 - Slide 1
|
Case 6 - Figure 1
Scanning magnification demonstrated a tumor that involved both the epidermis and dermis.
|
Case 6 - Figure 2
The tumor had a distinctly nested growth pattern.
|
Case 6 - Figure 3
Within the epidermis the tumor showed prominent upward pagetoid spread of tumor nests and individual tumor cells.
|
Case 6 - Figure 4
The tumor cells had uniform round to oval nuclei with a granular chromatin pattern.
|
for Text and References
Submitted by: Lori Erickson - Mayo Clinic College of Medicine, Rochester, MN
51 year old female presents with a "lesion" on the distal upper extremity.
Case 7 - Slide 1
|
for Text and References
Submitted by: Lori Erickson - Mayo Clinic College of Medicine, Rochester, MN
46 year old male with "lesion on nose, ?BCC".
Case 8 - Slide 1
|
Case 8 - Figure 1
Dermal based nodule comprised of pale staining epithelial aggregates.
|
Case 8 - Figure 2
Epithelial islands demonstrate cells with abundant cytoplasm and central nuclei with nuclear clearing.
|
Case 8 - Figure 3
Clear cells with abundant cytoplasm, large irregular nuclei with nuclear grooves.
|
Case 8 - Figure 4
Clear cells forming follicular structures surrounding areas of eosinophilic material.
|
|
|
|
|
Click to view with ImageScope
Click to view with a Web-Based Viewer
