2007 Gynecologic Pathology Specialty Conference Handout

— SPECIALTY CONFERENCE HANDOUT —

Gynecologic Pathology
Monday, March 26, 2007, 7:30 PM
CC 6 A/B/C/F

Moderator:

CHRISTOPHER P. CRUM
Brigham & Women's Hospital
Boston, MA

Disclosure: The speakers have indicated they have nothing to disclose.

Clinical histories and Virtual Slides as well as Still Images are displayed below.
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Case 1 - Click here for Text and References

Submitted by: Michael Deavers - The University of Texas, M.D. Anderson Cancer Center, Houston, TX

Clinical Summary:

A 64 year old woman presented with vaginal bleeding. The slide submitted is from her endometrial biopsy.

Case 1 - Slide 1

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Click to view with a Web-Based Viewer

Case 1 - Figure 1 - Low power microphotograph of the curetting

Case 1 - Figure 2 - Low power microphotograph of the curetting

Case 1 - Figure 3 - Higher magnification illustrates neoplastic glands

Case 1 - Figure 4 - Focal gland disorganization and desmoplasia

Case 1 - Figure 5 - Cribriform arrangements with a “garland” pattern

Case 1 - Figure 6 - Moderate to severe nuclear atypia

Case 1 - Figure 7 - Cribriform pattern with nuclear enlargement

Case 1 - Figure 8 - Luminal necrotic debris

Case 2 - Click here for Text and References

Submitted by: Brigitte Ronnett - The Johns Hopkins Hospital, Baltimore, MD

Clinical Summary:

36 year old woman ~7 weeks status post C-section (ovaries, cervix, and omentum described as normal at delivery) with a hypercoagulable state. In addition there are bilateral lower extremity deep vein thromboses complicated by pulmonary embolism. Enlarged supraclavicular and cervical lymph nodes were found and a biopsy of a cervical lymph node was performed (Images only).

Case 2 - Figure 1 - Scanning power image of the lymph node

Case 2 - Figure 2 - Higher magnification showing multiple cystic spaces

Case 2 - Figure 3 - Replacement of node parenchyma

Case 2 - Figure 4 - Higher magnification of malignant glands

Case 2 - Figure 5 - Solid and glandular growth patterns

Case 2 - Figure 6 - Well demarcated gland surrounded by solid growth

Case 2 - Figure 7 - Solid growth (center) merging with signet ring cells (left)

Case 2 - Figure 8 - Signet ring tumor cells

Case 3 - Click here for Text and References

Submitted by: C. Meg Mclachlin - University of Western Ontario, London, ON, Canada

Clinical Summary:

60 year-old woman with previous history of squamous cell and basal cell carcinomas of the face. She presents with a 0.8 cm white vulvar lesion with a rough surface; has been increasing in size over 13 months.