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Gastrointestinal biopsies constitute a major part of the practice of most surgical pathologists. Many GI biopsies are straightforward, but there are cases that regularly present diagnostic challenges and are sent to specialized gastrointestinal pathologists for consultation. This course is designed to address precisely those cases. Common GI consultation cases sent to the University of Michigan and Johns Hopkins Medical Institutions were selected for discussion. These cases include Barrett’s esophagus and ulcerative colitis surveillance biopsies, the colorectal adenoma that may or may not have a focus of invasive carcinoma, gastrointestinal spindle cell lesions, appendiceal mucinous and endocrine neoplasms, problematic biopsies from the ampulla of Vater, needle biopsies of masses in the liver, colitis that is difficult to classify, serrated polyps of the colon, and unusual patterns of pancreatitis.

Each case will be presented from the perspective of the submitting pathologist and from the perspective of the consultant GI pathologist. Then the audience will be presented with a selection of several possible discussions. Based on the audience response, one or more discussions will ensue. Pre-registrants will receive a website address where they can view case histories and images prior to the meeting. A syllabus will be distributed at the course. The entire course, including all of the optional discussions, will be available on the CD-ROM that will be mailed to registrants after the meeting.

The course is designed for advanced residents and practicing pathologists in any practice setting.

Upon completion of the course, participants will be able to use the strategies discussed to better handle the types of cases presented. In addition, registrants will have an updated perspective on the key issues to be addressed in biopsies from patients with these diseases.

This course may be used for CME credits or SAMs credits.