—  SPECIALTY CONFERENCE  — Genitourinary Tissue Pathology Tuesday, March 4, 2008 , 7:30 PM Convention Center 205/207 Click the button above to add this event to your Itinerary Planner... Moderator: PETER A. HUMPHREY Washington University School of Medicine St. Louis, MO Clinical histories are displayed below. For the fastest viewing of virtual slides, click: under each thumbnail image below. You must have Aperio ImageScope installed on your PC. If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy:   Or, click on slide thumbnail images to view each slide in a Web-based slide viewer, which is somewhat slower. If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137. Case 1 Submitted by: Hema Samaratunga - Sullivan Nicolaides Pathology, Brisbane, Australia Clinical Summary: A 52-year- old female presented with a two week history of right flank pain and gross hematuria. An ultrasound scan revealed a 5.5 cm mixed solid and cystic tumor in the lower pole of the right kidney. This was thought to be a renal cell carcinoma. There was no clinical or radiological evidence of metastatic cancer. A radical nephrectomy was performed. Involving the lower part of the kidney, there were several masses of tumor, the largest of which was partly cavitated. The tumor involved predominantly the medulla, with some involvement of the cortex and extension into the renal sinus and renal vein. The cut surface of the tumor was fleshy and white with haemorrhage and necrosis. Case 1 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 1 - Figure 1 Case 1 - Figure 2 Case 1 - Figure 3 Case 1 - Figure 4 Case 1 - Figure 5 Case 1 - Figure 6 Case 1 - Figure 7 Case 1 - Figure 8 Case 1 - Figure 9 Case 1 - Figure 10 Case 1 - Figure 11 - CAM 5.2 immunostain reveals that occasional tumor cells are positive. Case 2 Submitted by: Ferran Algaba - Fundacion Puigvert , Barcelona, Spain Clinical Summary: The clinical history is a 57 year old man with perineal pain and painful DRE. The PSA was 3.67 ng/L. The specimen is a core needle biopsy. Case 2 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 2 - Figure 1 Case 2 - Figure 2 Case 2 - Figure 3 Case 2 - Figure 4 Case 2 - Figure 5 - 34βE12 cytokeratin immunostain Case 2 - Figure 6 - 34βE12 cytokeratin immunostain Case 2 - Figure 7 - 34βE12 cytokeratin immunostain Case 3 Submitted by: Dengfeng Cao - Washington University School of Medicine, St. Louis, MO Clinical Summary: This is a 53-year old woman with a history of hysterectomy and bilateral salpingo-oophorectomies. She also had a history of nephrectomy for renal cell carcinoma. A recent follow-up CT scan showed a 4 cm mass in the posterior wall of the bladder. She underwent cystourethroscopy and transurethral resection of the mass. The specimen consisted of multiple fragments and the following pictures were taken from 3 representative fragments. Case 3 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 3 - Figure 1 Case 3 - Figure 2 Case 3 - Figure 3 Case 3 - Figure 4 Case 3 - Figure 5 Case 3 - Figure 6 Case 3 - Figure 7 Case 3 - Figure 8 Case 4 Submitted by: Victor E. Reuter - Memorial Sloan-Kettering Cancer Center, New York, New York Clinical Summary: Unilateral testicular tumor in a 15 month-old child. Case 4 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 4 - Figure 1 Case 4 - Figure 2 Case 4 - Figure 3 Case 4 - Figure 4 Case 4 - Figure 5 Case 4 - Figure 6 Case 4 - Figure 7 - CD99 immunostain Case 4 - Figure 8 - ER immunostain Case 5 Submitted by: Omar Hameed - University of Alabama School of Medicine, Birmingham, Alabama Clinical Summary: A 62-year old gentleman with intermittent urinary retention, previously managed medically, presents to his urologist with hematuria and increasing retention. Upon performing a transurethral resection of the prostate, the urologist noted “globs of mucus” in the prostate. Case 5 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 5 - Figure 1 Case 5 - Figure 2 Case 5 - Figure 3 Case 5 - Figure 4 Case 5 - Figure 5 Case 5 - Figure 6 Case 5 - Figure 7 Case 5 - Figure 8 If there are glass slides for a conference, they will be available for study in the microscope room in the Convention Center Room 101 for participants who wish to review them prior to the evening session. Handouts for all Specialty Conferences will be accessible via the "Educational Materials" section on the homepage the morning after each respective conference. Printed copies of the handout will not be available at the meeting. However, we will provide a booklet at the meeting which will have a page for each Specialty Conference, listing the names of speakers and space for the important "take home messages".