/* Sequence of slide descriptions */ desc01 = 'Case 1 - Figure 1 '; desc02 = 'Case 1 - Figure 2 '; desc03 = 'Case 1 - Figure 3 '; desc04 = 'Case 1 - Figure 4 '; desc05 = 'Case 1 - Figure 5 '; desc06 = 'Case 2 - Figure 1 '; desc07 = 'Case 2 - Figure 2 '; desc08 = 'Case 2 - Figure 3 '; desc09 = 'Case 2 - Figure 4 '; desc10 = 'Case 2 - Figure 5 '; desc11 = 'Case 3 - Figure 1 - Scanning magnification demonstrates a punch biopsy with a superficial and deep lymphoid infiltrate. Papillary dermal edema is present. '; desc12 = 'Case 3 - Figure 2 - Low power demonstrates a somewhat nodular infiltrate. '; desc13 = 'Case 3 - Figure 3 - Small aggregates of histiocytes form vague granulomas admixed with lymphocytes. '; desc14 = 'Case 3 - Figure 4 - Periadnexal infiltration is prominent. '; desc15 = 'Case 3 - Figure 5 - Large transformed lymphocytes and mitotic figures are present. '; desc16 = 'Case 3 - Figure 6 - Large transformed lymphocytes in addition to a vessel with plump reactive endothelial cells. An eosinophil is present under the vessel. '; desc17 = 'Case 3 - Figure 7 - Haloed lymphocytes line the dermal-epidermal interface and exocytosis is present. Some intraepidermal lymphocytes have convoluted nuclei. '; desc18 = 'Case 3 - Figure 8 - CD20 highlights a few admixed B-cells. '; desc19 = 'Case 3 - Figure 9 - The infiltrate is predominantly composed of CD4 + T-cells. '; desc20 = 'Case 3 - Figure 10 - Quite a few admixed cytotoxic T-cells are also present. '; desc21 = 'Case 3 - Figure 11 - CD30 highlights scattered cells throughout the infiltrate. '; desc22 = 'Case 3 - Figure 12 - A closer look demonstrates that CD30 is staining the large transformed lymphocytes. '; desc23 = 'Case 4 - Figure 1 - Scanning power shows a dense nodular infiltrate of small blue cells throughout the biopsy specimen. '; desc24 = 'Case 4 - Figure 2 - Closer view confirms the nodular architecture and cells appear to be lymphoid. '; desc25 = 'Case 4 - Figure 3 - Lymphocytes consist of a small to medium size population. '; desc26 = 'Case 4 - Figure 4 - Lymphocytes are infiltrating in and around skeletal muscle. '; desc27 = 'Case 4 - Figure 5 - Atypical and plasmacytoid forms are noted. '; desc28 = 'Case 4 - Figure 6 - Another view of atypical and plasmacytoid forms. '; desc29 = 'Case 4 - Figure 7 - CD3 highlights small admixed lymphocytes. '; desc30 = 'Case 4 - Figure 8 - CD20 highlights most of the infiltrate including atypical lymphocytes. '; desc31 = 'Case 4 - Figure 9 - In-situ hybridization reveals nuclear positivity for EBER in many of the large atypical lymphocytes. '; desc32 = 'Case 5 - Figure 1 - A nodular infiltrate is present in the dermis, 20x. '; desc33 = 'Case 5 - Figure 2 - The infiltrate is composed of a mixture of lymphocytes and histiocytes surrounding small vessels, 200x. '; desc34 = 'Case 5 - Figure 3 - Larger forms are admixed in the infiltrate, 400x. '; desc35 = 'Case 5 - Figure 4 - CD30-positive forms represent around 5 % of the infiltrate, 100x. '; desc36 = 'Case 5 - Figure 5 - The CD30-positive forms occur as single cells and small clusters, 400x. '; desc37 = 'Case 6 - Figure 1 - The lesion is polypoid with a somewhat nodular infiltrate, 20x. '; desc38 = 'Case 6 - Figure 2 - The infiltrate consists primarily of lymphocytes, 100x. '; desc39 = 'Case 6 - Figure 3 - At most, minimal cytologic atypia is noted, 400x. '; desc40 = 'Case 6 - Figure 4 - Very focal areas of necrosis and surrounding fibrosis are noted. '; desc41 = 'Case 6 - Figure 5 - The infiltrate consists primarily of CD3-positive T-cells, 40x. '; desc42 = 'Case 6 - Figure 6 - Nodules of CD20-positive B-cells are admixed, 100x. '; desc43 = 'Case 7 - Figure 1 - This low power image shows a dense lichenoid infiltrate with only minimal involvement of the superficial dermal vessels. This infiltrate has a CD3+/CD4+ predominance. '; desc44 = 'Case 7 - Figure 2 - Higher power reveals the epidermotropic infiltrate is composed of lymphocytes with enlarged nuclei and irregular nuclear contours. The perinuclear halo results from fixation-associated retraction of the atypical lymphocytes with abundant cytoplasm. In particular at the tips of the rete, the lymphocytes are seen aligned along the basilar keratinocytes. Notably, spongiosis, dyskeratosis, hyperkeratosis and parakeratosis are not present. '; desc45 = 'Case 7 - Figure 3 - The nuclear atypia is more apparent at this higher power. In addition to the atypical lymphocytes with perinuclear halos seen aligned along the basilar layer, collections of intraepidermal atypical lymphocytes, Pautrier microabscesses, are also noted. '; desc46 = 'Case 8 - Figure 1 - A dense dermal infiltrate with a vaguely nodular pattern is appreciated in this low power image. There is perifollicular and periadnexal involvement by this infiltrate. '; desc48 = 'Case 8 - Figure 2 - The mixed lympho-histiocytic nature of the infiltrate is noted at this higher power. Immunohistochemical staining reveals the cells with small hyperchromatic nuclei as well as some of the larger cells with open chromatin to be lymphocytes. There is mixed CD4+ and CD8+ expression in these lymphocytes. All these features support the reactive nature of the infiltrate. '; desc47 = 'Case 8 - Figure 3 - This higher power image confirms the heterogeneous population in this dermal infiltrate to be predominantly lymphocytes, histiocytes and plasma cells, along with plump endothelial cells. These features further support the reactive nature of this infiltrate. '; descv01 = 'Case 1 - Slide 1 '; descv02 = 'Case 2 - Slide 1 '; descv03 = 'Case 3 - Slide 1 '; descv04 = 'Case 4 - Slide 1 '; descv05 = 'Case 5 - Slide 1 '; descv06 = 'Case 6 - Slide 1 '; descv07 = 'Case 7 - Slide 1 '; descv08 = 'Case 8 - Slide 1 '; function parnav(imgnum) { parent.dir = '97th'; eval("parent.desc = desc"+imgnum); eval("parent.slidenum = 'derm"+imgnum+"'"); slidepop(); return; } function winstatus(imgnum) { eval("window.status = desc"+imgnum+";"); return; }