—  SPECIALTY CONFERENCE  — Pediatric Pathology Sunday, March 2, 2008, 7:30 PM Convention Center 111/113 Click the button above to add this event to your Itinerary Planner... Moderator: CHERYL COFFIN Primary Children's Medical Center Salt Lake City, UT Clinical histories are displayed below. For the fastest viewing of virtual slides, click: under each thumbnail image below. You must have Aperio ImageScope installed on your PC. If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy:   Or, click on slide thumbnail images to view each slide in a Web-based slide viewer, which is somewhat slower. If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137. Case 1 Submitted by: Julie Fanburg-Smith - Armed Forces Institute of Pathology, Washington, DC Clinical Summary: This 6-year old boy had a 2.5 cm intramuscular mass removed. The tumor was grossly circumscribed, multinodular, grey-pink and fleshy to firm. Case 1 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 1 - Figure 1 Case 1 - Figure 2 Case 1 - Figure 3 Case 1 - Figure 4 Case 1 - Figure 5 Case 1 - Figure 6 Case 1 - Figure 7 Case 1 - Figure 8 Case 1 - Figure 9 - MyoD1 Case 2 Submitted by: Rita Alaggio - Universita di Padova, Padova, Italy Clinical Summary: A 2-year old female was referred to the local hospital for failure to thrive. Family and personal health histories were negative. Ultrasound performed due to a suspicion of a urinary infection showed a voluminous abdominal mass. CT scans confirmed a solid lesion with necrotic areas in the right abdomen, extending to the left and right iliac fossa, adherent to liver, right kidney, cava and abdominal wall, and measuring 12 x 60 cm. An open biopsy was done. Histology was reviewed at the University of Padova and the child received 2 courses of chemotherapy (IVA2). Due to the poor response to therapy, child underwent surgery. The mass was resected with part of the omentum. Nodules from the anterior peritoneum, right iliac fossa, pelvis and sigma were also removed and gastric, peri-duodenal and mesentery lymph nodes were biopsied. After surgery, a new chemotherapy regimen (Ifosfamide/Adriamycin) was given. Six months later, the tumor recurred. A debulking operation was not considered possible. The child is alive with disease progression (multiple masses in the abdomen) after 2 years. The seminar slide originates from the primary resection. Case 2 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 2 - Figure 1 Case 2 - Figure 2 Case 2 - Figure 3 Case 2 - Figure 4 Case 2 - Figure 5 Case 2 - Figure 6 Case 2 - Figure 7 Case 3 Submitted by: Mark Lovell - Children's Hospital, University of Colorado Denver, Aurora, CO Clinical Summary: An obese 14-year old Hispanic male presented with 24 hours of gross hematuria, right flank pain, and frequent urination with blood present. He had mild, constant dull right flank pain without radiation. His BUN was 37 and creatinine was 3.8. CT scan showed a 3 cm well-circumscribed homogenous, hypervascular mass in the anterior medial-superior pole of the right kidney, which was excised. Multiple skin colored papules were noted on his cheeks and chin, with some small nodules on the nose, and a hypopigmented macule was present on his back. Multigenerational family members have similar skin lesions and his brother also had seizures. Case 3 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 3 - Figure 1 Case 3 - Figure 2 Case 3 - Figure 3 Case 3 - Figure 4 Case 3 - Figure 5 Case 3 - Figure 6 Case 3 - Figure 7 - CAM 5.2 Case 3 - Figure 8 - epithelial membrane antigen Case 3 - Figure 9 - melanoma-associated antigen Case 3 - Figure 10 - Oil Red O Case 3 - Figure 11 Case 4 Submitted by: Liliane Boccon-Gibod - Hopital d'Enfants A. Trousseau, Paris, France Clinical Summary: This young boy had unilateral gynecomastia, lentiginosis, and nasal polyposis. A testicular biopsy was performed. Case 4 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 4 - Figure 1 Case 4 - Figure 2 Case 4 - Figure 3 Case 4 - Figure 4 Case 4 - Figure 5 Case 4 - Figure 6 Case 4 - Figure 7 Case 4 - Figure 8 - inhibin Case 4 - Figure 9 - PAS Case 4 - Figure 10 - PAS If there are glass slides for a conference, they will be available for study in the microscope room in the Convention Center Room 101 for participants who wish to review them prior to the evening session. Handouts for all Specialty Conferences will be accessible via the "Educational Materials" section on the homepage the morning after each respective conference. Printed copies of the handout will not be available at the meeting. However, we will provide a booklet at the meeting which will have a page for each Specialty Conference, listing the names of speakers and space for the important "take home messages".