Collagenofibrotic Glomerulopathy J. Charles Jennette University of North Carolina Chapel Hill NC

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Click here to view (or print) handout in single page format. (3.08 MB) Note: Any slides will be printed in color. Click here to view (or print) black and white handout. (1.59 MB) Note: Text will be in single page format and any slides will be in 6-per-page format. Clinical History The patient was a 19 year-old Caucasian female with nephrotic range proteinuria. Laboratory data included blood pressure 110/80 mmHg, trace peripheral edema, no skin lesions, no hematuria, 4 to 5 grams of proteinuria per 24-hours, serum creatinine 0.6 mg/dl, creatinine clearance 90-110 ml/min, normal serum C3 and C4, negative ANA, and negative HBV serology. Light microscopy and electron microscopy images are available to evaluate. Immunofluorescence microscopy demonstrated slight granular mesangial and capillary wall staining for C3 but no staining for IgG, IgA, IgM, kappa light chains, lambda light chains, C1q or fibrin. Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Slide 2 Click to view with ImageScope Click to view with a Web-Based Viewer Slide 3 Click to view with ImageScope Click to view with a Web-Based Viewer   Figure 1 Low power view of cortex, H&E stain Figure 2 Representative glomerulus, high power, with H&E stain Figure 3 Representative glomerulus, high power, with PAS stain Figure 4 Representative glomerulus, high power, with trichrome stain Figure 5 Glomerulus stained with antibody to C3 (B&W) Figure 6 Electron micrograph of representative glomerulus Figure 7 Electron micrograph of representative glomerulus