REPORT OF THE 97th ANNUAL MEETING OF
THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY
March 1-7, 2008 - Denver, Colorado





The 97th annual meeting of the USCAP was held in Denver, Colorado and was by all accounts a resounding success. Three-thousand three hundred and fifty-eight (3358) physician-pathologists were in attendance.

The General Registration of the meeting was the second highest in the history of USCAP attendance (last year in San Diego being the highest ever-3550).
These attendance figures continue to make the annual meeting of the Academy the largest gathering, by far, of physician-pathologists in the world. Indeed, for the past seven years we have regularly had 3000 or more in attendance. 620 of the registrants/attendees at the Denver meeting were from international countries outside of the US and Canada. The countries (and the number of international visitors from each country) included: United Kingdom (54), Spain (48), Italy (46), Mexico (46), Netherlands (46), Japan (44), Australia (40), Korea (33), Brazil (30), Ireland (29), France (24), Germany (24), Greece (19), Argentina (17), Switzerland (16), Taiwan (16), Czech Republic (12), Turkey (10), and all the other countries 1-10 friends. Thus, in toto, 620 international visitors from sixty-one countries outside of the USA and Canada were in attendance (18.4 % of our total registrants). Pathologists from all 50 states of the US and 7 Canadian provinces were in attendance.

Of the registrants, 1818 were Regular, Sustaining or Emeritus members and 830 were Junior Members . There were 280 pathologists in practice who were not members and 186 residents/fellows who were not members (yet). Thus including the Residents, Monitors and other students, there were 1044 residents/fellows at our meeting. Each of the last several years we have had a thousand plus residents/fellows/students attend our Annual meetings. The percentage of house staff attending the meeting who are members of the Academy are for the past seven years - 41% , 69%, 67%, 66%, 76%, 84%, 88% respectively. This probably relates to the effective recruitment we have had of pathology house staff/fellows/pathologists-in-training in the last 8 years. In July 1999 we had 520 Junior Members; in the following eight-nine years we recruited over 5200 additional Junior Members (many of which have now become Regular Members). Our present "steady state" of Junior Members is over 2400. Our total USCAP Membership is over 10,600 physician-pathologists.

Dr. Chris Crum served a distinguished and quite active term as President of the USCAP. He turned over the gavel and the Presidency to Dr. Victor Reuter as the new President of the Academy.


2396 scientific abstracts were submitted for evaluation; tying last year’s all-time record in submitted abstracts
(all submitted electronically). The quality of the submitted abstracts remains very high. A record 1708 were accepted after "blind" peer review (71.3 % acceptance). The review is conducted by at least 4 individuals from the Academy (3 "experts" in the area and one from the Academy Education Committee). The percentage of acceptance is generally dependent upon the space available at the hotel (which is usually booked 5-6 years in advance of the meeting). 1428 abstracts were presented in the poster sessions (a record) and 280 as platform sessions. We try to accommodate as many quality poster sessions as space allows. Abstracts were submitted from throughout the world (from approximately 40 countries and about 350 academic medical centers and institutions). This was the sixth year for the USCAP to have electronic submission of our scientific abstracts (in conjunction with Marathon, Inc). These scientific abstracts are now online searchable by topic, disease, word, technique, author, institution, etc (www.uscap.org). The USCAP website: www.uscap.org consistently has the last three years of scientific abstracts (approximately 5000) which are now searchable by topic, disease, author, etc for the last 3 years.

As noted before, 1044 pathologists-in-training and students attended the various portions of the meeting. 58% of submitted scientific abstracts had a first author who is a pathologist-in-training
(compared to 38%, 43% and 53% the last three years). (this does not count the house staff/fellows that are second, third, etc authors). Over 376 Stowell-Orbison Abstracts were submitted. 238 were accepted for the Stowell-Orbison competition, and an additional 47 were accepted as regular abstracts (total 75.8 %). Once again, the "scores" for the accepted Stowell-Orbisons were actually higher than the scores for the "regular" abstracts accepted for presentation (i.e, Non-Stowell-Orbison). There were four co-equal Stowell-Orbison Awards presented and three Certificates of Merit. The recipients, in alphabetical order of first authors name, are as follows:

The recipients of the Stowell-Orbison Awards are:
Andrea N. Grin

Measuring Extent of DCIS in Breast Excision Specimens: A Comparison of Four Methods
AN Grin, G Horne, M Ennis, FP O'Malley
Mount Sinai Hospital, Toronto, ON, Canada; University of Calgary, Calgary, AB, Canada; Applied Statistician, Markham, ON, Canada
Crystal P. Jenkins

Utility of C4D Immunohistochemistry in Acute Myocardial Infarction
C Jenkins, D Cardona, S Normann
University of Florida, Gainesville, FL
Lynette M. Sholl

EGFR Gene Amplification Is Invariably Associated with Exon 19 Deletion in Non-Small Cell Lung Carcinoma
LM Sholl, AJ Iafrate, B Yeap, A Holmes, YP Chou, MT Wu, YG Goan, L Su, PA Jänne, DC Christiani, LR Chirieac
Brigham and Women's Hospital, Massachusetts General Hospital, and Dana Farber Cancer Institute, Boston, MA; Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan; Harvard School of Public Health, Boston, MA
Ron Yaar

Clinical Significance of Morphometric Measurements of Melanoma Metastatic to Single Sentinel Lymph Nodes
R Yaar, A Page, A Hestley, K Delman, GW Carlson, C Cohen
Emory University, Atlanta, GA




The recipients of the Stowell-Orbison Certificates of Merit are:
Hannah L. Gilmore

Impact of the New American Society of Clinical Oncology/College of American Pathologists Guidelines on the Determination of Breast Cancer HER2 Status
HL Gilmore, LC Collins, JL Connolly, SJ Schnitt
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
Rohit Mehra

TMPRSS2: ETS Gene Fusions in Androgen Independent Metastatic Prostate Cancers: An Association of TMPRSS2: ERG Fusions through Intronic Deletions and Molecular Evidence of Clonal Expansion
R Mehra, SA Tomlins, L Wang, A Menon, KJ Pienta, AM Chinnaiyan, RB Shah
University of Michigan, Ann Arbor, MI
Juan M. Mosquera

Characterization of TMPRSS2-ERG Fusion High-Grade Prostatic Intraepithelial Neoplasia and Potential Clinical Implications
JM Mosquera, S Perner, EM Genega, M Sanda, MD Hofer, KD Mertz, PL Paris, J Simko, TA Bismar, G Ayala, RB Shah, M Loda, MA Rubin
Brigham and Women's Hospital, Boston, MA; Harvard Med School, Boston, MA; Beth Israel Deaconess Med Centrr, Boston, MA; Univ of California, San Francisco, CA; McGill Univ, Montreal, QC, Canada; Baylor College of Medicine, Houston, TX; Univ of Michigan, Ann Arbor, MI




The ADASP/USCAP Autopsy Award winning abstract was:
Karen M. Jones

Sudden Cardiac Death in Non-Cardiac Primary Hematolymphoid Malignancy
KM Jones, EN Pavlikso, LR DiBernardo
Duke University Medical Center, Durham, NC




The ADASP/USCAP Surgical Pathology Award was:
Ruta Gupta

Lessons Learnt from Mistakes and Deferrals in Frozen Section Diagnosis of Pulmonary Lesions: An Evidence Based Pathology Approach
R Gupta, AS Khuranna, RJ McKenna, AM Marchevsky
Cedars Sinai Medical Center, LA, CA


658 registrants attended the Long Course entitled "Tumors of the Kidney and Urinary Bladder" by Drs. Eble and Grignon, Indiana University.
Early perusals of the critique form show that this course was very well done and very well liked by the registrants. The syllabus was complete/"long" (280 plus pages in length) and this Long Course includes a CD packed full of hundreds of images. This Long Course will be published in the next year in Modern Pathology.(Last year's Long Course on Targeted Therapy of Cancer: New Roles for Pathologists" is in the April 08 issue of Modern Pathology).

Sixty half-day Short Courses were presented and very well attended (with a total registration of Short Courses taken being 4852 (the second highest in history; last year’s record was 4923)
-that is the number of courses attended times the number of attendees at these sessions; an overall average of about 81 pathologists/per Short Course offering). From 1999 to the present time, the Academy has had regularly over 4000 in total registration each year. Virtually all of our Short Courses have CD's and many have "Virtual Slides".

Two all-day Special Courses
were offered: one on "Basic Principles and Practice of Molecular Pathology in Cancer" headed by Dr. Julia Bridge (Univ. Nebraska), was "sold out" attracting a maximum room number of 326 registrants on Monday. This course has a CD in addition to the extensive syllabus. The ongoing Advanced Molecular Pathology course headed by Dr. Frederic Barr, Univ. of Pennsylvania on Tuesday attracted 288 registrants and included a CD in addition to the extensive syllabus.

Twenty - Six Companion Societies
presented their educational endeavors on Saturday night and Sunday. The total registrations (number of attendees times the number of Companion Societies) was 2296, third highest in our history, after last year’s San Diego meeting (2347) and the record-setting ‘05' San Antonio meeting of 2371). For the past five years all of the Companion Societies and evening Specialty Conferences' handouts/syllabus have been placed on our website. (www.uscap.org) after the Annual meeting. This year was our third year for the Companions and the Specialties to go "paperless". All of the Companion Society handouts were on our USCAP Website at least 2-3 weeks before the meeting, and the Specialty Sessions had their unknowns (i.e., Clinical history and unknown slides) up more than one month before the Annual meeting, with the answers (i.e., text, powerpoints, references, answers, etc) up the morning after that evening Specialty Conference.

The Nathan Kaufman Timely Topic Lecture was given by Dr. Frank McKeon, Professor of Cell Biology from Harvard. The title of his lecture was "p63 Through the Ages". His lecture was elegant, timely, and very well received by the appreciative audience of over 2000 pathologists.


Dr. Chris Fletcher, Brigham & Women’s/Boston gave the Maude Abbot Lecture entitled: "The Future of Academic Anatomic Pathology: Challenges and Opportunities". This elegant and wonderful lecture was also attended by over 2200 pathologists. His was truly an outstanding presentation.


The Distinguished Pathologists Award
was presented this year to two individuals in recognition of their long-term, distinguished service in the development of the discipline of pathology and the USCAP: Drs. Nathan Kaufman and Bernard Wagner, recognized by the Academy membership for their major and extensive contributions to pathology over the years. Please see the USCAP Website (www.uscap.org) for their biosketches.

The President's Award was presented this year to Dr. Jack Perry Strong
. His dedication and work for the Academy and especially as long-standing Chair of the USCAP Finance Committee is way "above and beyond the call of duty". He received a very lengthy and vibrant standing-ovation! (And deserved it!). Please see the USCAP Website of the 2008 Annual Meeting for details about this outstanding and dedicated individual who have contributed so much to pathology world-wide.

The F.K. Mostofi Distinguished Service Award went to Dr. Richard Fraser, Montreal for
his important and extraordinary effort and success as President of the 2006 IAP Centennial Congress held in Montreal.

The Ramzi Cotran Young Investigator Award was presented to Dr. Anirban Maitra, Johns Hopkins.
The recipient of the Castleman Award (for the best published paper in the field of human pathology ) was Dr. Laurence de Leval (Belgium) for her paper entitled: "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (Tfh) cells" in Blood 2007: 109: 4952-4963.

The F. Stephen Vogel Award (for the most outstanding paper published in an Academy journal by a pathologist-in-training ) went to Dr. Jeremy Wallentine (Univ. of Utah) for his paper entitled: "
Comprehensive identification of proteins in Hodgkin lymphoma-derived Reed-Sternberg Cells by LM-MS/MS" in Laboratory Investigation: 2007 Nov; 87(11): 1113-1124, Epub 2007 Sep 17.

The 17 evening Specialty Conferences
, which are organ-based, were held from 7:30-9:30 PM, which was a testimony to the continuing endurance of the meeting's registrants. All of the evening Specialty Conferences are online on the Academy's website. For the past five years the unknowns (i.e., clinical history and representative histologic images) are placed on our USCAP website several weeks before the annual meeting, and the answers, complete text, references, etc are placed on our website the next morning after the Specialty Conference for all throughout the world to enjoy.

Additional activities of the Academy
have concentrated on the partnership of our two academy journals with the most outstanding medical and science publishing group in the world--Nature Publishing Group. Many of the top scientific breakthroughs of the 20th Century were first reported in the journal - Nature (it is the world's foremost weekly scientific journal by impact factor). Nature Publishing Group (NPG) publishes over 36 high profile society-owned or affiliated journals and 7-8 of the top 20 in the world in impact factor. Both of our Academy's journals now offer 2 pages of free color per published article, rapid advance online publication available 6 weeks after manuscript acceptance, increased international exposure, electronic table of content alerts delivered directly to your inbox highlighting new content each month, online submission of manuscripts and tracking, and reference cross-linking via CrossRef and MEDLINE. Powered by Naturejobs, the Career and Recruitment division of the journal Nature, Pathologyjobs provides recruiters with unique vehicles to advertise. Their Nature website is outstanding with free abstracts of all articles, integrated searches, online archives of all full-text articles from 2000 available through a personal or institutional subscription, and author index-which searches authors names across all available articles. This is a very powerful force in research and education for our members to utilize. In addition, the scientific abstracts for the past three years are now online and searchable. (Please see our USCAP and the Nature websites).

Other educational endeavors by the USCAP this past year include:


  1. The IAP Centennial Congress held in Montreal September 16-21, 2006. 2700 attendees (a record for the IAP Congresses) with individuals from almost 100 countries (also a record). A record number of scientific abstracts were submitted (from over 85 countries). >
  2. The establishment of the eAcademy (Go to: www.USCAPeAcademy.org for further information). This online, distance-learning tool, will render CME credit for a minor charge. This is under the Direction of Dr. John Sinard (Yale). The APECS cases (anatomic pathology cases) will start this summer, 2008.

  3. The First American Board of Pathology-approved "Self Assessment Module" (SAM): Diagnostic Cytopathology 07. We now have multiple SAM offerings: see the left-hand side of our USCAP Website for a listing of our "four sets" of SAM offerings. .

  4. The development of the CME Portfolio for members.

  5. Continuing involvement in altruistic activities, including West and Sub-Saharan Africa.

  6. Continuing growth of the free USCAP "Knowledge Hub/Pathology Portal"

  7. Over 500 Virtual Slides are now up on the USCAP Website for free (e.g., IAP Centennial; Annual evening Specialty Conferences)

  8. The "Naturization"of Laboratory Investigation (watch for future developments of this type for Modern Pathology coming very soon!)

  9. The development of the Itinerary Planner (electronic planner) for the Annual Meeting

  10. Online Membership Renewal and Registration

  11. A Poster Creation Service and ability to demonstrate entire abstract online

  12. Pod casts of the IAP Centennial KeyNote Addresses, and 2007 and 2008 Annual addresses.

  13. Online Evaluation of all of the Academy’s Courses

  14. And much more.


By action of Council, the USCAP instituted a Strategic Planning Initiative in 2003-2004 to look at the future of pathology and The Academy. Summer retreats (actually advances) directed by Dr. Jeffrey Myers have continued, and implementation of these educational goals and strategies have been implemented.

For the last four years, the Academy rolled out a number of new initiatives for our Junior members
including: Several programs for pathologists-in-training were instituted-- including the Fellowship Fair with 40-55 institutions to discuss hundreds of fellowships; the new evening Specialty Conference just for house staff/fellows; and the House Staff Hospitality Room where Academy and Pathology leaders from throughout North America were present to talk with the house staff.

The USCAP's annual summer pathology review course and update- Diagnostic Pathology
, with its fourteen outstanding faculty will be held in Hawaii in July. It is Directed by Drs. Greg Fuller (MD Anderson) and Stuart Schnitt (BID, Boston). (See www.uscap.org for complete schedule). Last year’s course (07) came with a 1100 page handout and a 3800 image CD-ROM!

This was the third year for the USCAP Winter (January) Course entitled "Diagnostic Cytopathology" under the initiation, leadership and direction of Dr. Celeste Powers
(Virginia Commonwealth University, Richmond). This 2 l/2 day weekend intense and advanced course was held at the Carefree Resort north of Scottsdale/Phoenix, Arizona. The 700 plus page handout and the extensive CD (with over a thousand images) were very well received. There were 70 individuals in attendance. We will be doing another winter Diagnostic Cytopathology course next year in January 2009 to be held in Tampa, Florida

The educational initiative of the USCAP is Practical Pathology Seminars, in its second year, under the direction of Dr. John Goldblum
(Cleveland Clinic) . It will be held from April 25-27, 2008 in Clearwater Beach (Tampa), Florida. Five short courses will be given on topics including: Gyn, Breast, GU, Molecular Surgical Pathology and Soft Tissue Tumors by eight outstanding faculty.

Next year's annual USCAP meeting will be held in Boston, Massachusetts from March 7-13, 2009.
The Long Course entitled "Breast Pathology" will be directed by Stuart Schnitt and Frances O’Malley. As usual there will be an extensive handout/syllabus and a CD with a great many images.

There are several additions to our USCAP Committees
: Four new members of the Education Committee (under the Direction of Dr. John Goldblum) are: Drs. Celina Kleer (Univ. Michigan), Robert Hasserjian (MGH/Boston); Tarik Tihan (UCSF), and Qihui (Jimmy) Zhai (Methodist/Houston).

Dr. Stu Schnitt, BID/Boston, is by vote of the membership the new Vice-President of the Academy, and Dr. Richard Zarbo (Henry Ford, Detroit) is President-Elect. The newly elected (by the Academy membership) Council members are: Frances O’Malley (Toronto), Mary Richardson (Charleston), and Allen Gown (Seattle)


Dr. Jack Strong (LSU) steps down as the head of the Finance Committee, which will now be headed by Dr. Peter Banks and our newest member is Dr. John Eble. The Publications Committee previously chaired by Dr. Allen Gown will now be chaired by Dr. Ronald DeLellis with Dr. Bruce Smoller as our newest member. The newest members of the Young Investigator Committee are Drs. Allen Gown, Frances O’Malley, and Tony Yachnis. New Members of the Castleman Award Committee include: Drs. Max Loda, Jeffrey Saffitz and Judith Ferry. New members of the Vogel Award Committee are Drs. Adam Bagg and Volkan Adsay. Dr. Jennifer Hunt will join Dr. Bill Gardner as a member of the Pathology Section Council at the AMA House of Delegates. All of the members of the various USCAP Committees are noted on our website (www.uscap.org).

The new at-large member of the Nominating Committee (under the Direction of Dr. Chris Crum) is Dr. Cheryl Coffin. If you have nominations for Council (or any available committee position) please let the central Augusta office know (fsilva@uscap.org).

Please check the USCAP Website (www.uscap.org) for an immense number of educational materials which are free. Over five year's worth of evening Specialty Conferences and Companion Society's materials are up as well over three dozen of excellent, ended Short Courses and available to anyone who wishes to utilize them. In addition, as noted before, three successive years of our scientific abstracts are now online and searchable, and can be downloaded, as well as many Short Courses. That's over 5000 searchable cutting-edge scientific abstracts! We also have a Table of Contents by 24 plus organ systems/subspecialties of our nineteen hundred entries/modules for all to have for free. Our USCAP Website continues to have record-setting hits with over 5.0 million hits in January 2007 from 22,000 individual pathologists from throughout the world (85 countries) with over 600,000 total page views that month. The USCAP is happy to provide this free altruistic service for pathologists throughout the world. Go to: www.uscap.org for the largest eBook in the history of anatomic and diagnostic molecular pathology, for free

At present the USCAP membership is in excess of 10,600 pathologists (from 77 countries in addition to the US and Canada); over 2300 of those are Junior Members. We continue to grow and be vibrant. It is clear that our colleagues in pathology are a very dedicated and professional lot. We are proud to be associated with them.

Thanks for all your support for all those we serve--our patients, our physicians and our students.

Hope to see you in Tampa, Hawaii, and Boston.

 


Fred Silva, Secretary-Treasurer and Executive Vice President, USCAP
March 11, 2008