Proteomics refers to the collective multi-faceted approaches used to study various aspects of protein expression, organization and function at a global level. There is much interest in every aspect of biologic research in the field of proteomics due to recent advances in mass spectrometry and advanced bioinformatic technologies.

The course will provide a background on the principles and concepts of proteomics and discuss major technologic platforms currently in use. Various applications of proteomics that are relevant to the current and future practice of pathology including protein microarrays, quantitative protein profiling and serum biomarker discovery will be presented. Case studies by which proteomic strategies are used for evaluation and development of new biomarkers and the translation of their discoveries into novel clinical applications will be presented.

This course is designed for residents and practicing pathologists with interest in biomarker discovery and analysis and who seek to keep updated on technological advances. A comprehensive syllabus will be distributed at the course.

Upon completion of the course, participants should be familiar with key components of proteomics, basic methods for global analysis of proteins, proteomic strategies for elucidation of deregulated pathways involved in disease pathogenesis and the potential role of high throughput proteomic approaches such as protein microarrays in the discovery of disease biomarkers.

(New Course) This course may be used for CME credits or SAM’s credits.