Gynecologic Pathology

Metastatic Poorly Differentiated Endometrioid Adenocarcinoma Arising in Adenomyosis

Lora Hedrick Ellenson
Weill Medical College of Cornell University
New York, NY


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Clinical History:
35-year-old G0 woman with a unilateral adnexal cystic mass.


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Mucicarmine
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CK7

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CK20
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ER

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PR
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WT-1


Differential Diagnosis:
  • Metastatic gastric carcinoma

  • Poorly differentiated carcinoma of the ovary

  • Metastatic endometrial carcinoma

Final Diagnosis:
Metastatic poorly differentiated endometrioid adenocarcinoma arising in adenomyosis

References:
  1. Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients. Walsh MD et al. Clin Cancer Res. 2008 March 15; 4(6):1692-700.

  2. Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Zighelboim I et al. J Clin Oncol. 2007 May 20; 25(15):2042-8.

  3. Utility of immunohistochemistry in predicting microsatellite instability in endometrial carcinoma. Modica I et al. Am J Surg Pathol. 2007 May; 31(5):744-51.

  4. Body mass index: relationship to clinical, pathological and features of microsatellite instability in endometrial cancer. McCourt CK et al. Gynecol Oncol. 2007 Mar;104(3):535-9.