SPECIAL COURSE Tuesday, March 10, 2009   —  8:00 AM - 1:15 PM Convention Center BRC ADVANCED MOLECULAR PATHOLOGY Click the button above to add this event to your Itinerary Planner... COURSE DIRECTORS: Frederic G. Barr, M.D., Ph.D. University of Pennsylvania Philadelphia, PA This special course will provide an in-depth consideration of recent advances in molecular biology and genetics that are enhancing the understanding of the pathogenesis of human cancer and other diseases, and impacting on the practice of diagnostic pathology. Topics will be chosen to highlight specific advances in the molecular and cell biology related to disease pathogenesis, with considerations of molecular mechanisms of tumorigenesis, the role of basic genetic and biochemical signaling pathways, the impact of microbiology and immunology, and a variety of methodologic approaches. The program is designed as an update for both practicing pathologists and primary investigators on these specific topics as well as general trends in the field of molecular pathology. In addition to presenting a basic scientific foundation on each topic, each lecture will provide practical information concerning how this information can be applied in diagnostic and therapeutic settings. Therefore, an important overall emphasis of this course will be translational issues that link basic discoveries with the practice of pathology. AGENDA 8:00 Introduction Frederic G. Barr, M.D., Ph.D. 8:10 Pathology of Ovarian Cancer: Lessons from Morphology, Molecules and Mice Kathleen R. Cho, M.D., University of Michigan Medical School 8:55 Molecular Pathology of Allograft Rejection Tricia Bhatti, M.D., The Children’s Hospital of Philadelphia 9:40 Primary Characterization of the Merkel Cell Polyoma Virus and Its Role in Human Neoplasia Yuan Chang, M.D., University of Pittsburgh Cancer Institute 10:25 Coffee break 10:45 Gene Methylation for Diagnosis, Prognosis and Predictive Classification of Cancer Paul Cairns, Ph.D., Fox Chase Cancer Center 11:30 Autophagy and the Brain: A Delicate Balance between Neuroprotection and Neuropathology Kevin A. Roth, M.D., Ph.D., University of Alabama at Birmingham 12:15 Biological Classification of Breast Cancer Torsten O. Nielsen, M.D., Ph.D. FRCPC, University of British Columbia 1:00 Concluding Remarks and Questions