Glomerular lesions encompass a variety of pathogenetic mechanisms and clinical presentations which influence the interpretation of the morphologic findings observed by light, immunofluorescence and electron microscopies. This course addresses glomerular pathology by providing an initial review of anatomy, terminology, clinical syndromes and techniques used in renal biopsy interpretation. Subsequently, there will be a case-based approach to the common glomerular abnormalities in the context of the presenting clinical syndrome. The case presentations will cover primary and secondary diseases with the use of all methods of renal biopsy evaluation. Discussions of the cases will incorporate pathogenetic mechanisms including involvement in systemic disorders and current classification systems as appropriate. Transplant-associated glomerular lesions will not be included.

At the end of the course, participants will be able to 1) recognize basic patterns of glomerular injury by light, immunofluorescence and electron microscopies; 2) correlate these glomerular processes with clinical syndromes and symptoms; 3) diagnose the common glomerular disorders with respect to the clinical presentation; and 4) understand the pathogenetic underpinnings of primary and secondary glomerular lesions.

The course is intended for residents, fellows in renal pathology and practicing pathologists as well as those with an interest in electron microscopy and immunopathology. Pre-registrants will receive a website address where they can view the images and case histories prior to the meeting. A CD containing case histories and material for other cases and will be mailed with the glass slides to pre-registrants prior to the meeting. A comprehensive syllabus will be distributed at the course and a CD with representative images will be mailed to all participants following the meeting.

(Last Scheduled Presentation) This course may be used for CME credits or SAM's credits.