SPECIAL COURSE

Monday, March 22, 2010   —  7:50 a.m. – 1:00 p.m.

BASIC PRINCIPLES AND PRACTICE OF MOLECULAR PATHOLOGY IN CANCER



COURSE DIRECTOR:
Julia A. Bridge, M.D., FACMG
Department of Pathology & Laboratory Medicine
University of Nebraska Medical Center
Omaha, Nebraska

Course Description
Accumulating discoveries of the biological mechanisms that control cell growth and differentiation, and developments in the clinical management of cancer, continue to expand the role of molecular technology in diagnostic surgical pathology. In this course, the basic principles of molecular pathology in cancer and their application to laboratory medicine will be emphasized in a format designed to be practical and straightforward. Specifically, this course is aimed at providing pathologists with a foundation in the practice of oncologic molecular pathology to include: nomenclature, commonly used techniques and their specimen requirements, assay selection and indications, diagnostic and prognostic utility, test turn-around-times, and quality assurance issues. Select cases may be presented to illustrate use in routine practice and serve as useful paradigms. Moreover, specific areas will be highlighted in which major advances can be expected and to which the basic principles learned can be applied.

Course Objectives:

  • to present an overview of the basic genetic principles of common oncologic molecular diagnostic testing

  • to provide participants with a working knowledge of tests available in oncologic molecular pathology as well as their application and interpretation in screening, diagnosis, monitoring, and treatment of cancer
Introduction
Julia A. Bridge, M.D., FACMG, University of Nebraska Medical Center, Omaha, NE
Cytogenetic and Molecular Genetic Testing in Bone and Soft Tissue Tumors
Julia A. Bridge, M.D.
Integration of the Molecular Classification of Breast Cancer into Current Practice
Allen M. Gown, M.D., PhenoPath Laboratories, Seattle, WA and University of British Columbia, Vancouver, BC
Molecular Predictive Markers for Targeted Therapies of Lung Cancer
Marc Ladanyi, M.D., Memorial Sloan-Kettering Cancer Center, New York, NY
Molecular Diagnostics of Gliomas
Arie Perry, M.D., Washington University School of Medicine, St. Louis, MO
The Basis and Rational Use of Molecular Testing in Lymphoma
Adam Bagg, M.D., University of Pennsylvania, Philadelphia, PA
Molecular Pathology of Thyroid and Parathyroid Neoplasia
Jennifer L. Hunt, M.D., M.Ed,; Massachusetts General Hospital, Boston, MA
Colorectal Carcinoma: Molecular Pathology and Clinical Practice
Stanley R. Hamilton, M.D., The University of Texas M.D. Anderson Cancer Center, Houston, TX
Emerging Understanding of Gene Fusion Prostate Cancer
Mark A. Rubin, M.D., Weill Cornell Medical College, New York, NY
Question Period and Concluding Remarks