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Sunday, March 21, 2010 — 8:30 AM, Thurgood South
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- Avoiding Pitfalls in the Diagnosis of Soft Tissue Tumors
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Moderators:
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David Howell, Duke University Medical Center, Durham, NC and
John Hicks, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX
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Disclosure:
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In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Symposium) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. The speakers listed below have indicated they have nothing to disclose.
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Note: Text will be in single page format and any slides will be in 6-per-page format.
Click any blue title below to display and print the handout for individual lecture(s):
| 8:30 | Molecular Diagnosis of Soft Tissue Tumors: Avoiding Pitfalls - Cristina Antonescu, Memorial Sloan-Kettering Cancer Center, New York, NY |
| 9:15 | Ultrastructural Diagnosis of Soft Tissue Tumors: Avoiding Pitfalls - Allan Tucker, University of S. Alabama, Mobile, AL |
| 9:40 | Ultrastructural Diagnosis of Pediatric Soft Tissue Tumors: Avoiding Pitfalls - John Hicks, Texas Children's Hospital, Baylor College of Medicine, Houston, TX |
| 10:00 | Break |
| 10:30 | Surgical Pathology Diagnosis of Soft Tissue Tumors: Avoiding Pitfalls - Christopher Fletcher, Brigham and Women's Hospital, Boston, MA |
| 11:15 | Cytogenetic Diagnosis of Soft Tissue Tumors: Avoiding Pitfalls - Julia Bridge, Nebraska Health System, Omaha, NE |
As established diagnostic modalities (e.g., electron microscopy) mature and newer techniques (e.g., molecular diagnostics) evolve, it is critical to recognize both the strengths and the potential shortcomings of each method. As diagnosticians, investigators, and teachers, we have a natural tendency to emphasize the strengths of our diagnostic tools, sometimes overlooking the pitfalls. Recognizing the limitations of each technique is important in any diagnostic area, but is particularly crucial in a field like soft tissue tumor pathology, where many of the neoplasms are rare, recently described, and have confusing or overlapping histologic features.
The 2010 Society for Ultrastructural Pathology USCAP Companion Meeting will provide an overview of pitfalls in the diagnosis of soft tissue tumors using ultrastructural, histologic, cytogenetic, and molecular diagnostic approaches. The multidisciplinary approach is designed to highlight complementarity of the different methods, including situations where relative weaknesses in one or more methods are compensated for by strengths of others. Electron microscopy and routine histology, for example, provide an "open view" of a vast range of tissue alterations, but are often incapable of identifying the molecular or biochemical abnormalities underlying the pathology. Molecular and cytogenetic techniques can probe the latter nuances, but require an a priori notion of what's wrong to guide reagent selection.
Objectives for the session include: 1) Provide an overview of the applications and pitfalls of ultrastructural pathology, surgical pathology, cytogenetics, and molecular diagnostic methods in the diagnosis of soft tissue tumors. 2) Probe the relative strengths and shortcomings of each technique, and identify areas of complementarity between them. 3) Identify a rational approach for the concerted use of the various techniques to solve a diagnostic problem. |
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