Virginia A. LiVolsi, M.D. , and Zubair W. Baloch, M.D., Ph.D., Hospital of University of Pensylvania, Philadelphia, PA and Sylvia L. Asa, M.D., Ph.D., University Health Network, Toronto, ON
The pathologic evaluation of the lesions of endocrine organs can be a difficult task due to lack of well-defined morphologic criteria and subtle functional alterations leading to subtle or marked cellular atypia. This course will offer practical hints based on presenters' experience and literature that can aid in the diagnosis of fine-needle aspiration specimens, intraoperative consultations, as well as histology, with conventional histopathology and immunohistochemicaland molecular diagnostic tools.
Using a case study approach, this course will illustrate and discuss the following seven diagnostic problem areas: (1) the value and limitations of fine needle aspiration cytology of endocrine tissues with focus on thyroid FNA; (2) the use and abuse of intraoperative consultations, with frozen sections and cytologic touch preparations; (3) the criteria for and the clinical significance of distinguishing endocrine hyperplasia from neoplasia and their clinical consequences; (4) definitions of capsules and capsular invasion as a criterion of malignancy in endocrine tumors; (5) the significance of cellular or architectural atypia, mitoses, necrosis and ploidy alterations in endocrine tumors; (6) the definition and significance of oncocytic change in endocrine cells, tissues and tumors; and (7) the role of histochemical, immunohistochemical and molecular markers in defining cell differentiation, function and clinical behavior in endocrine lesions.
This course is intended for general pathologists, pathologists with special expertise in the area, and residents. Pre-registrants will be provided a link where they can view virtual images prior to the course. A course syllabus will be distributed at the meeting. After the meeting, participants will receive by mail a CD containing the course material.
(New Course) This course may be used for CME credits or SAM's credits.