—  SPECIALTY CONFERENCE  — Dermatopathology Tuesday, March 23, 2010, 7:30 PM Salon 2 Issues in the Evaluation of Melanocytic Lesions Moderator: STEVEN R. TAHAN Beth Israel Deaconess Medical Center, Boston, MA Disclosure: In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Symposium) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. The speakers listed below have indicated they have nothing to disclose. Panelists: MARTIN C. MIHM, Harvard Medical School, Massachusetts General Hospital, Boston, MA GEORGE F. MURPHY, Harvard Medical School, Brigham and Women's Hospital, Boston, MA STEVEN R. TAHAN, Harvard Medical School and Beth Israel Deaconess Medical School, Boston, MA ROY KING, Knoxville Dermatopathology Laboratory, Knoxville, TN Clinical histories are displayed below. For the fastest viewing of virtual slides, click: under each thumbnail image below. You must have Aperio ImageScope installed on your PC. If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy:   Or, click on slide thumbnail images to view each slide in a Web-based slide viewer, which is somewhat slower. If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137. Case 1 Submitted by: Roy King - Knoxville Dermatopathology Laboratory, Knoxville, TN Clinical Summary: 63 Year old male presented to his dermatologist with a pigmented lesion on his right posterior shoulder. The patient was unaware of the duration of the lesion and has a history of multiple benign moles removed from his back. His wife noticed this lesion and is not sure if this was a site of previous biopsy. Case 1 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 2 Submitted by: Steven R. Tahan - Harvard Medical School and Beth Israel Deaconess Medical School, Boston, MA Clinical History: This nevus was shaved from the neck of a 35 year old woman who was 29 weeks pregnant for indication of increasing size. Case 2 - Figure 1 Case 2 - Figure 2 Case 2 - Figure 3 Case 2 - Figure 4 Case 2 - Figure 5 Case 2 - Figure 6 Case 2 - Figure 7 Case 2 - Figure 8 Case 2 - Figure 9 MIB-1 Case 2 - Figure 10 HMB45 Case 3 Submitted by: Martin C. Mihm - Harvard Medical School, Massachusetts General Hospital, Boston, MA Clinical Summary: At age 8 this boy developed a mole on the posterior scalp. His parents thought that it was the result of a "bug bite." the lesion gradually became raised and intermittently bled. By age 13 it was large and ulcerated. The parents had been treating it with a variety of herbal medicines and other remedies. He began to wear a hat to cover the area. The lesion became so large that it bled almost daily. Finally, after much taunting by other children and after much bleeding he sought medical advice. A biopsy was taken. Case 3 - Figure 1 Case 3 - Figure 2 Case 3 - Figure 3 Case 3 - Figure 4 Case 3 - Figure 5 Case 4 Submitted by: George F. Murphy - Harvard Medical School, Brigham and Women's Hospital, Boston, MA Clinical Summary: A 59-year-old man presented with a 4mm brown papule on the left calf. Shave biopsy was performed and is represented in images 1-7. Fourteen months later, left inguinal adenopathy was noted and a lymph node dissection was performed (representative image of node - images 8-10 [s100 stain=image 10]). Case 4 - Figure 1 Case 4 - Figure 2 Case 4 - Figure 3 Case 4 - Figure 4 Case 4 - Figure 5 Case 4 - Figure 6 Case 4 - Figure 7 Case 4 - Figure 8 Case 4 - Figure 9 Case 4 - Figure 10 Handouts for all Specialty Conferences will be accessible via the "Educational Materials" section on the homepage the morning after each respective conference. Printed copies of the handout will not be available at the meeting.