—  SPECIALTY CONFERENCE HANDOUT  — Gynecologic Pathology Wednesday, March 24, 2017, 7:30 PM Salon 2 Clinical histories are printed below. Click on the case numbers for text and references of each case. Click on each slide thumbnail image for an enlarged view Ovarian Cancer Moderator: ROBERT J. KURMAN Johns Hopkins Hospital, Baltimore, MD Disclosure: In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Symposium) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. The speakers listed below have indicated they have nothing to disclose. Panelists: PATRICIA A. SHAW, University of Toronto, Toronto, Ontario, Canada ELVIO SILVA, Anderson Cancer Center, Houston, TX; Cedars-Sinai Medical Center, Los Angeles, CA; Baylor Hospital, Dallas, TX KATHLEEN R. CHO, University of Michigan Medical School, Ann Arbor, MI IE-MING SHIH, Johns Hopkins University School of Medicine, Baltimore, MD Clinical histories are displayed below. For the fastest viewing of virtual slides, click: under each thumbnail image below. You must have Aperio ImageScope installed on your PC. If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy:   Or, click on slide thumbnail images to view each slide in a Web-based slide viewer, which is somewhat slower. If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137. Case 1 - Click here for Text and References Submitted by: Patricia A. Shaw - Toronto General Hospital, Toronto, Ontario, Canada Clinical Summary: Modified radical hysterectomy, bilateral salpingo- oophorectomy and lymph node dissection is performed on a 56 year old woman with adenocarcinoma diagnosed on Pap smear and endocervical curettage. Case 1 - Figure 1 Striking multifocal epithelial proliferation Case 1 - Figure 2 Stratification with tufting and budding Case 1 - Figure 3 Marked nuclear atypia Case 1 - Figure 4 Carcinoma metastasis on ovarian surface Case 1 - Figure 5 High grade serous carcinoma Case 1 - Figure 6 Carcinoma with focal ovarian stromal invasion Case 2 - Click here for Text and References Submitted by: Elvio Silva - Anderson Cancer Center, Houston, TX; Cedars-Sinai Medical Center, Los Angeles, CA; Baylor Hospital, Dallas, TX Clinical Summary: This is a 58 year old female who was diagnosed with an ovarian neoplasm in December 1997. Pertinent Laboratory Data: List of treatments: December 97 – Surgery – Toxol and CisPlatinin X6 June 2000 – Recurrence – Toxol and Hexalen July 2002 – Recurrence – Topotecan September 2002 – Doxcil, Hemcetavine December 2003 – BP 16 March 2004 – Tamoxifen July 2015 – Arymidex December 2015 – Pain medicine Case 2 - Figure 1 Case 2 - Figure 2 Case 3 - Click here for Text and References Submitted by: Kathleen R. Cho - University of Michigan Medical School, Ann Arbor, MI Clinical History: 46 year old woman with strong family history of ovarian cancer and bilateral ovarian masses. Case 3 - Figure 1 Endometriosis adjacent to fallopian tube Case 3 - Figure 2 Portion of ovary with carcinoma involving endometriotic cyst Case 3 - Figure 3 Photomicrographs show carcinoma with features most pathologists associate with endometrioid differentiation: solid and near-solid areas of growth admixed with well formed glands, many with round/ovoid lumens Case 3 - Figure 4 Photomicrographs show carcinoma with features most pathologists associate with endometrioid differentiation: solid and near-solid areas of growth admixed with well formed glands, many with round/ovoid lumens Case 3 - Figure 5 Photomicrographs show carcinoma with features most pathologists associate with endometrioid differentiation: solid and near-solid areas of growth admixed with well formed glands, many with round/ovoid lumens Case 3 - Figure 6 Photomicrographs show carcinoma with features most pathologists associate with endometrioid differentiation: solid and near-solid areas of growth admixed with well formed glands, many with round/ovoid lumens Case 4 - Click here for Text and References Submitted by: Ie-Ming Shih - Johns Hopkins University School of Medicine, Baltimore, MD Clinical Summary: A 42 y/o nulligravid Asian female presented with increasing intra-abdominal lymphadenopathy shortly after carboplatin/paclitaxel treatment for her previous "ovarian carcinoma" in an outside hospital. Unfortunately, the original tumor tissue was not available to review at that moment. She developed postoperative venous thromboembolism. Past history was significant for endometriosis. The sections were obtained from lymph node dissection. Case 4 - Figure 1 The tumor shows a heterogeneous growth pattern including microcysts, solid and glandular features. Case 4 - Figure 2 Cytologically, the tumor cells contain moderately atypical nuclei with infrequent mitotic figures. The cytoplasm is not particularly clear. Hyalinization in tumor stroma is also appreciated. Case 4 - Figure 3 Cytologically, the tumor cells contain moderately atypical nuclei with infrequent mitotic figures. The cytoplasm is not particularly clear. Hyalinization in tumor stroma is also appreciated. Handouts for all Specialty Conferences will be accessible via the "Educational Materials" section on the homepage the morning after each respective conference. Printed copies of the handout will not be available at the meeting.