XXVI International Congress of the
International Academy of Pathology
Montreal, Quebec, Canada




Slide Seminar 05 - Mimics in Surgical Pathology

Sunday, September 17, 2006 14:00 - 17:30




  Moderators: Dr. Sunil Lakani and Dr. Salam Al-Sam
  Disclosure: In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Slide Seminar) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. Faculty members for this Slide Seminar have indicated they have no disclosures to make.



Clinical histories are displayed below.
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Case 1 - Atypical Marginal Zone Hyperplasia Of Mucosa Associated Lymphoid Tissue: A Reactive Condition Of Childhood Showing Immunoglobulin Lambda Light Chain Restriction

Submitted by: Dr. Ahmet Dogan

Clinical History:

4 year old girl with unilateral palatine tonsil enlargement causing breathing difficulty


Case 1 - Figure 1
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Case 2 - Endometrial Complex Atypical Hyperplasia with Extensive Squamous Metaplasia

Submitted by: Dr. Frederique Penault-Llorca

Clinical History:

A 27 year old woman consulted the gynaecologist for infertility. The specimen is a curettage product.


Case 2 - Figure 1
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Case 3 - Pseudoepitheliomatous Hyperplasia Mimicking Squamous Cell Carcinoma in Association with a CD30+ Lymphoproliferative Disorder

Submitted by: Dr. Jaime Colonje

Clinical History:

A 77 year old man presented with an 8 week history of rapidly enlarging non-painful papule on left side of abdomen, initially size of a pea. Increased over next 8 weeks into an ulcerated nodule. Intermittent bleeding secondary to trauma. He had extensive cardiac problems. No other lesions, no peripheral palpable lymphadenopathy. Treated with oral and topical antibiotics without effect.


Case 3 - Figure 1
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Case 4 - So-called "Sclerosing Hemangioma"

Submitted by: Dr. Osamu Matsubara

Clinical History:

The patient was a 67 years old Japanese woman with a history of sigmoidectomy for sigmoid colon cancer. Pathological examination revealed that this cancer was well differentiated adenocarcinoma with invasion into the subserosal layer. Two months later, a chest X-ray and CT scans of the thorax showed a coin lesion in the right lower lobe. She underwent tumorectomy of this lung nodule by video-assisted thoracosurgery (VATS). The clinical diagnosis was metastatic lung cancer.


Case 4 - Figure 1
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Case 5 - Sclerosing Adenosis of the Prostate

Submitted by: Dr. Hema Samaratunga

Clinical History:

A 68-year-old male presented in July 2002 with an elevated PSA of 13.19 ng/ml (normal 4.5). His serum PSA had been progressively increasing since 1997, when it was 4.5. He had some associated lower urinary tract symptoms. Digital rectal examination (DRE) revealed a smooth prostate. On transrectal ultrasound (TRUS), the transition zone was enlarged and the volume was estimated to be about 85 g. He underwent a TRUS guided prostatic biopsy in August 2002, and this was reported as benign with chronic prostatitis. He continued to have urinary symptoms and his PSA continued to climb and was up to 16.9 in December 2004 when he underwent a repeat biopsy. This again showed no evidence of malignancy, but had atrophy with acute inflammatory changes. He continued to have obstructive lower urinary tract symptoms and presented for a TURP when 60 g of prostatic tissue was removed. This was reported as nodular prostatic hypertrophy with Gleason score 3+4 = 7 prostatic adenocarcinoma involving 5% of the tissue. Post operatively, his urinary symptoms improved significantly and his PSA reduced to 3.9. PSA was at about the same level when he was last seen in May 2005.


Case 5 - Figure 1
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Case 6 - Juxtaoral Organ of Chievitz - a Diagnostic Pitfall

Submitted by: Dr. Michal Michal

Clinical History:

58 year old man had an excision of soft tissue adjacent to the mandible.


Case 6 - Figure 1
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Case 7 - Granulomatous Mastitis

Submitted by: Dr. Salam Al-Sam

Clinical History:

52 year-old woman presented with a unilateral breast mass. Mammography demonstrated an ill-defined opacity. Physical examination revealed a firm/hard mass, 3 cm in size (P5 R3). Fine Needle Aspiration was performed and reported as C5 malignant. Mastectomy and axillary sampling was performed based on high clinical and cytological suspicion.




Case 8 - Microglandular Adenosis in Association with Invasive Ductal Carcinoma

Submitted by: Dr. Sunil Lakani

Clinical History:

A 72 year old woman presented with a 27mm lump in her breast. Initial investigations suspicious for malignancy, lump excised.


Case 8 - Figure 1
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Case 9 - Pseudosarcomatous ('Reactive') Myofibroblastic Proliferation

Submitted by: Dr. Christopher D.M. Fletcher

Clinical History:

A 33 year old female presented with haematuria. At cystoscopy, the urologist identified a fleshy focally necrotic 3cm mass. Transurethral resection was performed.


Case 9 - Figure 1
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