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Slide Seminar 11 - Genitourinary Pathology
Tuesday, September 19, 200608:00 - 12:00
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Moderators:
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John R. Srigley and Rodolfo Montironi
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Disclosure:
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In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Slide Seminar) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. Lawrence True indicated he is a consultant and has grant/research support from Glaxo-Smith-Kline. All other faculty members for this Slide Seminar have indicated they have no disclosures to make.
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Clinical histories are displayed below.
Click on the case numbers to display the text and references for each case.
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- Renal Medullary Carcinoma
Submitted by: Athanase Billis
A 25-year-old black male was hospitalized due to macroscopic hematuria. Computerized tomography (CT) revealed a solid, expansile mass measuring 7cm in greatest diameter in the lower pole of the right kidney. The patient underwent a radical nephrectomy.
Case 1 - Slide 1
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- Carcinoma Cuniculatum of Penis
Submitted by: Antonio Cubilla
83-year-old patient with a foul smelling exophytic mass involving the distal portion of the glans. The lesion was slowly-growing for the past 4 years. A biopsy revealed a well-differentiated verrucous squamous cell carcinoma. A partial penectomy was performed.
Case 2 - Slide 1
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- Phyllodes Tumor of the Prostate Gland
Submitted by: Edward C. Jones
A 48-year-old man presented with obstructive renal failure secondary to an enlarged prostate gland. After treatment by transurethral curettage, the patient was lost to follow-up. Two years later he presented with recurrent renal failure. A repeat transurethral curettage removed 23 grams of tissue. The HE section is representative of this second curettage specimen.
Case 3 - Slide 1
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- Clear Cell Carcinoma of Bladder
Submitted by: Esther Oliva
A 78 year-old woman presented with hematuria of 2 months duration. A cystoscopic exam revealed a large polypoid broad based lesion located at the trigone and extending up into the bladder. Vaginal examination was unremarkable. The patient underwent a transurethral resection of the mass.
Case 4 - Slide 1
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- Seminoma with Intertubular Growth
Submitted by: Pedro L. de Oliveira
A 31 year-old-male presented with a right sided spermatocele. An echographic evaluation of the scrotal contents showed an ill-defined 12mm area near the hilus on the left side. During excision of the spermatocele a surgical evaluation of both testis was performed and since no visible or palpable abnormality was present bilateral testicular biopsies were done (Slide 1). A radical left orchidectomy was subsequently performed. (Slide 2).
Case 5 - Slide 1
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Case 5 - Slide 2
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- Angiomyofibroblastoma–like Tumor of Scrotum
Submitted by: Hema Samaratunga
A 63-year-old male presented with a painless left scrotal mass, which was first noted a few weeks previously. There were no associated symptoms. The mass was found to be external to the testis. A radical orchidectomy was performed in continuity with the mass.
Case 6 - Slide 1
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- Tubulocystic Carcinoma of Kidney
Submitted by: Mathilde Sibony
A 56-year-old male had a left lower pole kidney mass discovered by ultrasonography performed for urinary symptoms related to prostate hypertrophy. The lesion measured 3cm in diameter and had imaging characteristics of a benign tumor. A smaller renal mass in the right kidney, with typical characteristics of renal cell carcinoma was simultaneously discovered. The urologists decided to perform a needle biopsy (slide 1), followed by a local resection (tumorectomy) of the left sided tumor (slide 2).
Case 7 - Slide 1
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Case 7 - Slide 2
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- Effects of Therapy (Radiation, Hormones and Chemotherapy) on the Prostate Gland
Submitted by: Lawrence True
The 62-year-old male underwent needle biopsy of the prostate following a serum screening PSA of 22 ng/ml. The biopsy revealed adenocarcinoma of the prostate, Gleason combined score 4 + 3 = 7 of 10. Since the patient was deemed to be at "high risk of recurrence" he was entered into a neoadjuvant trial of Mitaxantrone-Taxotere, after which he underwent radical prostatectomy with lymph node dissection.
Case 8 - Slide 1
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