Section 3 -

Milestones in the Pathology of Renal Neoplasia 1950 to Present John Eble

1957 First series AFIP fascicle published (B. Lucké and H.G. Schlumberger. Atlas of Tumor Pathology, Fascicle 30, Tumors of the Kidney, Renal Pelvis and Ureter, Washington, D.C: Armed Forces Institute of Pathology, 1957) 1963 Radical nephrectomy established (C. J. Robson. Radical nephrectomy for renal cell carcinoma. J Urol 89:37-42, 1963) 1967 Congenital mesoblastic nephroma is recognized (R. P. Bolande, A. J. Brough, and R. J. Izant, Jr. Congenital mesoblastic nephroma of infancy, a report of eight cases and the relationship to Wilms' tumor. Pediatrics 40:272-278, 1967) 1967 Juxtaglomerular cell tumor is recognized (P. W. Robertson, A. Klidjian, L. K. Harding, G. Walters, M. R. Lee, and A. H. T. Robb-Smith. Hypertension due to a renin-secreting renal tumour. Am J Med 43:963-976, 1967 and Kihara, S. Kitamura, T. Hoshino, H. Seida, and T. Watanabe. A hitherto unreported vascular tumor of the kidney: a proposal of "juxtaglomerular cell tumor". Acta Pathol Jpn 18:197-206, 1968) 1969 Robson staging system is proposed (C. J. Robson, B. M. Churchill, and W. Anderson. The results of radical nephrectomy for renal cell carcinoma. J Urol 101:297-301, 1969) 1969 National Wilms Tumor Study Pathology Center is established under the direction of Dr. J. Bruce Beckwith 1970 Clear cell sarcoma of kidney is recognized (J.M. Kidd. Exclusion of certain renal neoplasms from the category of Wilms' tumor. Am J Pathol 59:16a, 1970 AND E. Morgan and J. M. Kidd. Undifferentiated sarcoma of the kidney, a tumor of childhood with histopathologic and clinical characteristics distinct from Wilms' tumor. Cancer 42:1916-1921, 1978.) 1975 Second series AFIP fascicle published (J. L. Bennington and J. B. Beckwith. Atlas of Tumor Pathology, Second Series, Fasicle 12, Tumors of the Kidney, Renal Pelvis, and Ureter, Bethesda:Armed Forces Institute of Pathology, 1975) 1976 Papillary renal cell carcinoma is recognized (R. Mancilla-Jimenez, R. J. Stanley, and R. A. Blath. Papillary renal cell carcinoma, a clinical, radiologic, and pathologic study of 34 cases. Cancer 38:2469-2480, 1976) 1976 Renal oncocytoma (M. J. Klein and Q. J. Valensi. Proximal tubular adenomas of kidney with so-called oncocytic features, a clinicopathologic study of 13 cases of a rarely reported neoplasm. Cancer 38:9096-914, 1976) 1978 Significance of anaplasia in Wilms' tumor is recognized (J. B. Beckwith and N. F. Palmer. Histopathology and prognosis of Wilms tumor, results from the First National Wilms' Tumor Study. Cancer 41:1937-1948, 1978) 1978 Rhabdoid tumor of kidney is recognized (J. B. Beckwith and N. F. Palmer. Histopathology and prognosis of Wilms tumor, results from the First National Wilms' Tumor Study. Cancer 41:1937-1948, 1978) 1980 Metanephric adenoma is recognized (A. Pagès and M. Granier. Le néphrome néphronogène. Arch.Anat.Cytol.Pathol. 28:99-103, 1980) 1982 Nuclear grading of renal cell carcinoma is established (S. A. Fuhrman, L. C. Lasky, and C. Limas. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655-663, 1982) 1985 Chromophobe renal cell carcinoma is recognized (W. Thoenes, S. Störkel, and H.-J. Rumpelt. Human chromophobe cell renal carcinoma. Virchows Arch.[B] 48:207-217, 1985) 1986 Importance of chromosome 3p in clear cell renal cell carcinoma is recognized (M. A. Yoshida, K. Ohyashiki, H. Ochi, Z. Gibas, J. E. Pontes, G. R. Prout, Jr., R. Huben, and A. A. Sandberg. Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma. Cancer Res 46:2139-2147, 1986) 1986 Mainz classification of renal cell tumors proposed (W. Thoenes, S. Störkel, and H.-J. Rumpelt. Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas) the basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181:125-143, 1986) 1987 The importance of the renal sinus for spread of Wilms' tumor is recognized (D. A. Weeks, J. B. Beckwith, and D. W. Luckey. Relapse-associated variables in stage I favorable histology Wilms' tumor, a report of the National Wilms' Tumor Study. Cancer 60:1204-1212, 1987) 1988 Eosinophilic variant of chromophobe renal cell carcinoma is recognized (W. Thoenes, S. Störkel, H.-J. Rumpelt, R. Moll, H.-P. Baum, and S. Werner. Chromophobe cell renal carcinoma and its variants--a report on 32 cases. J Pathol 155:277-287, 1988) 1989 Partial nephrectomy becomes well-established (A. C. Novick, S. Streem, J. E. Montie, J. E. Pontes, S. Siegel, D. K. Montague, and M. Goormastic. Conservative surgery for renal cell carcinoma: A single-center experience with 100 patients. J Urol 141:835-839, 1989) 1990 Nephrogenic rests are recognized as precursors of Wilms tumor (J. B. Beckwith, N. B. Kiviat, and J. F. Bonadio. Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumor. Pediatr Pathol 10:1-36, 1990) 1991 Characteristic gains of chromosomes are recognized in papillary renal cell carcinoma. (G. Kovacs, L. Fuzesi, A. Emanuel, and H.-F. Kung. Cytogenetics of papillary renal cell tumors. Genes Chromosom Cancer 3:249-255, 1991) 1992 Characteristic losses of chromosomes are recognized in chromophobe renal cell carcinoma (A. Kovacs and G. Kovacs. Low chromosome number in chromophobe renal cell carcinomas. Genes Chromosom Cancer 4:267-268, 1992) 1992 Metanephric adenofibroma is recognized (R. A. Hennigar and J. B. Beckwith. Nephrogenic adenofibroma, a novel kidney tumor of young people. Am J Surg Pathol 16:325-334, 1992) 1993 Mixed epithelial and stromal tumor is recognized (A. Pawade, G. N. Soosay, W. Delprado, M. C. Parkinson, and J. Rode. Cystic hamartoma of the renal pelvis. Am J Surg Pathol 17:1169-1175, 1993) 1994 Third series AFIP fascicle published (W. M. Murphy, J. B. Beckwith, and G. M. Farrow. Atlas of Tumor Pathology, Third Series, Fascicle 11, Tumors of the Kidney, Bladder, and Related Urinary Structures, Washington, D.C.:Armed Forces Institute of Pathology, 1994) 1995 Medullary carcinoma is recognized (C. J. Davis, Jr., F. K. Mostofi, and I. A. Sesterhenn. Renal medullary carcinoma: the seventh sickle cell nephropathy. Am.J.Surg.Pathol. 19:1-11, 1995) 1996 Epithelioid angiomyolipoma is recognized (K. T. Mai, D. G. Perkins, and J. P. Collins. Epithelioid variant of renal angiomyolipoma. Histopathology 28:277-280, 1996) 1996 Theory of perivascular epithelioid cell origin for angiomyolipoma is proposed (G. Zamboni, M. Pea, G. Martignoni, C. Zancanaro, G. Faccioli, E. Gilioli, P. Pederzoli, and F. Bonetti. Clear cell "sugar" tumor of the pancreas, a novel member of the family of lesions characterized by the presence of perivascular epithelioid cells. Am J Surg Pathol 20:722-730, 1996) 1997 Types 1 and 2 papillary renal cell carcinoma are recognized (B. Delahunt and J. N. Eble. Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol 10:537-544, 1997) 1997 International consensus classifications of renal cell neoplasia are published (G. Kovacs, M. Akhtar, J. B. Beckwith, P. Bugert, C. S. Cooper, B. Delahunt, J. N. Eble, S. Fleming, B. Ljungberg, L. J. Medeiros, H. Moch, V. E. Reuter, E. Ritz, G. Roos, D. Schmidt, J. R. Srigley, S. Störkel, E. van den Berg, and B. Zbar. The Heidelberg classification of renal cell tumours. J Pathol 183:131-133, 1997 AND S. Störkel, J. N. Eble, K. Adlakha, M. Amin, M. L. Blute, D. G. Bostwick, M. Darson, B. Delahunt, and K. A. Iczkowski. Classification of renal cell carcinoma, workgroup 1. Cancer 80:987-989, 1997) 1999 Dr. J. Bruce Beckwith retires and Dr. Elizabeth Perlman becomes director of the National Wilms Tumor Study Pathology Center 1999 Carcinoma associated with neuroblastoma is recognized (L. J. Medeiros, G. Palmedo, H. R. Krigman, G. Kovacs, and J. B. Beckwith. Oncocytoid renal cell carcinoma after neuroblastoma: a report of four cases of a distinct clinicopathologic entity. Am J Surg Pathol 23:772-780, 1999) 1999 Mucinous tubular and spindle cell carcinoma is recognized (J. R. Srigley, J. N. Eble, D. J. Grignon, and R. W. J. Hartwick. Unusual renal cell carcinoma (RCC) with prominent spindle cell change possibly related to the loop of Henle. Mod Pathol 12:107A, 1999 AND A. V. Parwani, A. N. Husain, J. I. Epstein, J. B. Beckwith, and P. Argani. Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation. Hum Pathol 32:506-512, 2001) 2000 Metanephric stromal tumor is recognized (P. Argani and J. B. Beckwith. Metanephric stromal tumor, report of 31 cases of a distinctive pediatric renal neoplasm. Am J Surg Pathol. 24:917-926, 2000) 2001 Translocation carcinomas are is recognized (P. Argani, C. R. Antonescu, P. B. Illei, M. Y. Lui, C. F. Timmons, R. Newbury, V. E. Reuter, A. J. Garvin, A. R. Perez-Atayde, J. A. Fletcher, J. B. Beckwith, J. A. Bridge, and M. Ladanyi. Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol 159:179-192, 2001 AND P. Argani, A. Hawkins, C. A. Griffin, J. D. Goldstein, M. Haas, J. B. Beckwith, C. B. Mankinen, and E. J. Perlman. A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. Am J Pathol 158:2089-2096, 2001) 2004 The importance of the renal sinus for spread of renal cell carcinoma is recognized (S. M. Bonsib. The renal sinus is the principal invasive pathway, a prospective study of 100 renal cell carcinomas. Am J Surg Pathol 28:1594-1600, 2004) 2004 Fourth series AFIP fascicle published (W. M. Murphy, D. J. Grignon, and E. J. Perlman. AFIP Atlas of Tumor Pathology, Fourth Series, Fascicle 1, Tumors of the Kidney, Bladder, and Related Urinary Structures, Washington, D.C.:American Registry of Pathology, 2004) 2004 WHO classification published (J.N. Eble, G. Sauter, J.I. Epstein, and I.A. Sesterhenn (eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs, Lyon:IARC Press, 2004) 2005 Laparoscopic nephrectomy becomes well-established (Y. Ono, R. Hattori, M. Gotoh, Y. Yoshino, Y. Yoshikawa, and O. Kamihira. Laparoscopic radical nephrectomy for renal cell carcinoma: the standard of care already? Curr Opin Urol 15:75-78, 2005)