Christopher P. Crum
Born: Newport News, Virginia
- BA University of Virginia, Charlottesville, Virginia, 1970
- MD University of Virginia, Charlottesville, Virginia, 1974
- 1981 - 1987 Assistant Professor of Pathology, Columbia University College of Physicians and Surgeons, New York City, New York
- 987 - 1990 Associate Professor of Pathology and Associate Professor of Obstetrics and Gynecology, University of Virginia Medical School, Charlottesville, VA
- 1990 Associate Professor, Professor (1997) of Pathology, Harvard Medical School, Boston, MA
- Medical University of South Carolina, Charleston, South Carolina
- University of Virginia Medical Center, Charlottesville, Virginia
- Columbia University College of Physicians and Surgeons, New York City
Selected Career Highlights
Directs the large clinical and research program in Women's and Perinatal Pathology at Brigham and Women's Hospital.
Trained at Columbia University with Saul Silverstein (with help from a Physician Scientist Award from the National Institute of Allergy and Infectious Disease), also with Cecilia Fenoglio and Ralph Richart.
While at Virginia had joint appointments in Pathology, ObGyn and Micro.
Major interests in Gynecologic Pathology, genital papillomaviruses and cervical intraepithelial neoplasia. Author of the first papers ( New England Journal of Medicine and Journal of Virology ) to link HPV 16 with high-grade cervical intraepithelial neoplasia of the cervix, confirming that CIN was the result of HPV infection and established the link between high-grade CIN and invasive cancer by virtue of their association with HPV 16. Was among the first to propose a binary grading system for early CIN, similar to that subsequently proposed in the Bethesda System a few years later for cytologic diagnosis.
Published widely on the topic of lower genital tract neoplasia and HPV, identifying unique subsets of cervical and vulvar neoplasia based upon their relationship (or lack of ) to HPV, and was among the first groups that identified two distinct categories of vulvar squamous neoplasia. Subsequently established that monoclonality and allelic imbalance occurred in vulvar mucosa prior to the onset of morphologic atypia
In association with Dr. Frank McKeon mapped expression of the p53 homolog p63 in genital mucosa. The first group to identify reserve cells in the endometrium.
Recent interests include the pathogenesis of high-grade serous carcinomas of the ovary. Shown that a very high percentage of these in women with BRCA mutations actually originate in the distal fallopian tube. His group has established a possible tubal origin for nearly one-half of serous "ovarian" carcinomas and "primary peritoneal" carcinomas. Has identified a candidate serous cancer precursor in benign appearing tubal mucosa (the "p53" signature).
Has authored nearly 200 articles, 40 chapters and reviews and three books.
Conducted a series of USCAP Short Courses for 18 consecutive years.
Initiated a series of "Hands-on" courses in Ob/Gyn at Brigham and Women's which is in the 15th year. With colleagues established the first interactive course in Ob/Gyn Pathology at the USCAP in 2006 and has introduced "video microscopy" to complement the lectures in this field.
Member, Editorial Boards including:
- Advances in Anatomic Pathology
- Diagnostic Surgical Pathology
- Gynecologic Pathology
- International Journal of Gynecologic Pathology
- Modern Pathology
Lives in Brookline, MA with his wife, Tucker, (who is on the faculty at Wellesley College) and has two daughters Emily Day and Amanda Gibson.